Thermoregulation and Aging

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue of Brain Science dedicated to the reciprocal relationship between aging and temperature. Temperature was the first parameter scientifically demonstrated to influence lifespan when, in 1916, Jac Loeb and John Northrop set out to determine whether a temperature coefficient for the duration of life existed. Yet, the role of temperature on the biology of aging remained poorly investigated compared to that of calorie restriction, first described by Clive McCay in 1935, or that of the genetic pathways whose discovery have sparked a resurgence of interest in the mechanisms of aging in the past twenty years. This is partly because the effects of temperature were considered to be exclusively thermodynamic. However, work from laboratories around the world is providing novel evidence indicating that temperature might affect aging via specific genetic pathways. Another aspect of the relationship between temperature and aging is the effects that aging has on temperature homeostasis. The ability to maintain a proper core body temperature against different environmental temperatures is typically reduced with age, affecting survival in harsh conditions (i.e., extremely hot summers).

Temperature and aging exert a reciprocal influence on each other: temperature can regulate longevity and aging affects temperature homeostasis. We aim to present research form laboratories around the world investigating the relationship between temperature and aging. Cutting-edge research articles describing original and novel findings are particularly welcome. We invite original and novel work on the relationship between temperature and aging as well as comprehensive reviews on the same subject. We will also consider a limited number of commentaries on the subject that could stimulate discussion and future progress in the field.

Prof. Dr. Bruno Conti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Temperature
• aging
• metabolism
• healthspan
• homeostasis
• longevity