Molecular Mechanisms in Neuronal Cells Induced by Air Pollution and Their Involvement in Neurodegenerative Diseases
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 8560
Special Issue Editor
2. POLARIS Research Centre, University of Milano-Bicocca, 20126 Milano, Italy
Interests: air pollution outdoor; PM2.5; ultrafine particles; in-vivo and in-vitro models; neurodegenerative diseases infiammatory and oxidant biochemical cellular pathway; anti-inflammatory and antioxidant properties of phytoextracts
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Air pollutants are released into the atmosphere and can cause significant harm to humans. According to the World Health Organization (WHO), around 3.5 million people die each year because of urban and indoor air pollution, making this a leading environmental health risk. PM can be classified according to its size: PM10 (≤10 um); PM2.5 (≤2.5 um), and PM0.1 (smaller than 100 nm, also known as ultrafine particles (UFPs), which includes nanoparticles (NPs)). Of these, UFPs have the potential to exert significant harm, as particles of this size can escape scavenging by alveolar macrophages. These particles also penetrate deep into the respiratory tract where they can be absorbed by the bloodstream. Although there is an increasing assumption that UFPs are deleterious to human health, very little is known about the cellular, molecular, and genetic/epigenetic alterations that may affect the incidence/severity of chronic disease in individuals exposed to UFPs. Deposition patterns have revealed that the lungs are the primary target, although particles have been detected in other organs including the liver, kidney, heart, and brain. UFPs are also the most consistently implicated in adverse neurological processes. PM is known to be a persistent source of neuroinflammation and reactive oxygen species (ROS), processes strongly related to the pathogenesis of central nervous system (CNS) diseases. Accordingly, air pollution exposure is associated with exacerbated cognitive dysfunction and enhanced progression of neurodegenerative processes underlying Alzheimer’s and Parkinson’s diseases as well as adverse vascular effects. In addition, a relationship between stroke and air pollution has been established over the past decade. Thus, this Special Issue of Brain Sciences aims to examine the molecular mechanisms elicited by air pollution and their association with CNS pathologies.
Prof. Paola Palestini
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Air Pollution
- Nervous System
- Inflammation
- Oxidative Stress
- Neurodegenerative Disease
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
