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Article

Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children

1
Faculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech Republic
2
Institute of Experimental Medicine CAS, 142 20 Prague, Czech Republic
3
Hospital Ceske Budejovice, a.s., 370 01 Ceske Budejovice, Czech Republic
4
Faculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(9), 619; https://doi.org/10.3390/brainsci10090619
Received: 29 July 2020 / Revised: 31 August 2020 / Accepted: 4 September 2020 / Published: 7 September 2020
Objectives: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 from Karvina (Northern Moravia, n = 70) and Ceske Budejovice (Southern Bohemia, n = 99) were studied at the age of five years for their cognitive development related to the exposure to PAHs, determined in the ambient air as the concentration of benzo[a]pyrene (B[a]P) and OH–PAH (hydroxy-PAH) metabolites in urine of the newborns at the time of delivery. As psychological tests, the Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used. Results: Concentrations of B[a]P in the third trimester of mother’s pregnancies were 6.1 ± 4.53 ng/m3 in Karvina, and 1.19 ± 1.28 ng/m3 (p < 0.001) in Ceske Budejovice. Neither the outcome of the RCPM test nor the BG test differed between children in Karvina vs. Ceske Budejovice, or boys vs. girls. Cognitive development in five year old children was affected by the higher exposure to PM2.5 during the third trimester in girls in Karvina. Conclusions: We did not observe any significant effect of prenatal PAH exposure on psychological cognitive tests in five year old children. View Full-Text
Keywords: polycyclic aromatic hydrocarbons; OH–PAH metabolites in urine; psychological tests; cognitive development; Bender Visual Motor Gestalt Test; Raven Colored Progressive Matrices polycyclic aromatic hydrocarbons; OH–PAH metabolites in urine; psychological tests; cognitive development; Bender Visual Motor Gestalt Test; Raven Colored Progressive Matrices
MDPI and ACS Style

Blazkova, B.; Pastorkova, A.; Solansky, I.; Veleminsky, M., Jr.; Veleminsky, M.; Urbancova, K.; Vondraskova, V.; Hajslova, J.; Pulkrabova, J.; Sram, R.J. Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children. Brain Sci. 2020, 10, 619. https://doi.org/10.3390/brainsci10090619

AMA Style

Blazkova B, Pastorkova A, Solansky I, Veleminsky M Jr., Veleminsky M, Urbancova K, Vondraskova V, Hajslova J, Pulkrabova J, Sram RJ. Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children. Brain Sciences. 2020; 10(9):619. https://doi.org/10.3390/brainsci10090619

Chicago/Turabian Style

Blazkova, Barbora, Anna Pastorkova, Ivo Solansky, Milos Veleminsky Jr., Milos Veleminsky, Katerina Urbancova, Veronika Vondraskova, Jana Hajslova, Jana Pulkrabova, and Radim J. Sram 2020. "Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children" Brain Sciences 10, no. 9: 619. https://doi.org/10.3390/brainsci10090619

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