Challenges and Future Trends of Neuroendocrinology-Related Diseases

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Systems Neuroscience".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 3225

Special Issue Editors


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Guest Editor
College of Medicine and Health Sciences, UAE University, Al Ain P.O. Box 15551, United Arab Emirates
Interests: anatomy; diabetes; metabolism; cardiovascular research; neuroendocrinology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
Interests: anatomy; bone tissue; engineering; biomaterials; bone biology; diabetes; imaging

Special Issue Information

Dear Colleagues,

Neuroendocrinology-related diseases arise from a discordance in the normal relationship between the nervous and endocrine systems. Contemporary developments in science, technology, AI, and medicine have opened new avenues for the diagnosis and management of these disorders.

This Special Issue, ‘Challenges and Future Trends of Neuroendocrinology-Related Diseases’ aims to collate papers that address the most recent and novel advancements related to the pathophysiology, pathology, risk factors, pharmacotherapy, and management protocols for the prevention and management of neuroendocrinology-related diseases.

We invite submissions of original articles, reviews as well as clinical trials from researchers working in the field of neuroendocrinology, including molecular and cell biologists, physiologists, pathologists, pharmacologists, and clinicians.

Prof. Dr. Ernest Adeghate
Dr. Sahar Mohsin
Guest Editors

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Keywords

  • diabetes insipidus
  • neuroendocrine tumors
  • the role of neuroendocrine axis in the development of diabetes mellitus
  • disease related to the brain-atrial natriuretic peptide system
  • disorders of the brain-angiotensin system
  • AI in neuroendocrinology
  • brain hormones (e.g., ghrelin and galanin) in endocrine disorders

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Published Papers (1 paper)

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Review

17 pages, 2507 KiB  
Review
The Enigma That Is ROHHAD Syndrome: Challenges and Future Strategies
by Katherine Hawton, Dinesh Giri, Elizabeth Crowne, Rosemary Greenwood and Julian Hamilton-Shield
Brain Sci. 2024, 14(11), 1046; https://doi.org/10.3390/brainsci14111046 - 23 Oct 2024
Viewed by 2576
Abstract
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare syndrome presenting in early childhood associated with a high risk of mortality between 50 and 60%. It is characterised by rapid, early onset of obesity between 1.5–7 years, along with [...] Read more.
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare syndrome presenting in early childhood associated with a high risk of mortality between 50 and 60%. It is characterised by rapid, early onset of obesity between 1.5–7 years, along with central hypoventilation and hypothalamic dysfunction, such as central hypothyroidism, hyperprolactinemia, disorders of sodium and water balance, growth hormone deficiency, adrenocortical insufficiency, or disorders of puberty and features of autonomic dysregulation. Up to half of cases have neural crest tumours, most commonly ganglioneuromas or ganglioneuroblastomas. The incidence of ROHHAD syndrome in any population is unknown. Currently, there is no specific diagnostic or genetic biomarker for ROHHAD, and diagnosis is based on clinical signs and symptoms, which is often challenging, and consequently may be delayed or unrecognised. Early diagnosis is important, as without intervention, ROHHAD is associated with high morbidity and mortality. Aetiology remains unclear; an autoimmune origin has been postulated, with immunosuppressive agents being used with variable benefit. With no cure, multidisciplinary management is largely supportive. Therefore, there are many unanswered questions in ROHHAD syndrome. In this review article, we outline the challenges posed by ROHHAD syndrome, including aetiology, genetics, diagnosis, screening, management, and prognosis. We present research priorities to tackle these issues to improve outcomes. Full article
(This article belongs to the Special Issue Challenges and Future Trends of Neuroendocrinology-Related Diseases)
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