Pathological Mechanisms of Neurodegenerative Diseases Associated with Altered Mitochondrial Function and Quality Control
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (8 October 2019) | Viewed by 3426
Special Issue Editor
Interests: mechanisms of neurodegeneration in Parkinson’s disease and Alzheimer’s disease; role of serine/threonine kinases in regulating mitochondrial function, turnover, and oxidative stress in neurons; mechanisms of neurite outgrowth and dendrite branching by mitochondrial serine/threonine kinases; mechanisms of modulation of mitochondrial trafficking in neurons
Special Issue Information
Dear Colleagues,
Neurons predominantly rely on high-quality mitochondria to provide the necessary energy demands required to maintain essential neuronal functions and neuronal connectivity. In order for neurons to maintain a level of high quality mitochondria, mitochondria must undergo constant fission and fusion, traffic to sites of high-energy demand, and continuously undergo turnover (mitophagy) and regeneration (biogenesis). Indeed, the high reliance of neurons on high quality mitochondria is evident as mitochondrial dysfunction underlies the etiology of many neurodegenerative disorders including but not limited to Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Huntington’s disease. However, the pathological mechanisms by which mitochondrial abnormalities contribute to the loss of neuronal connectivity and cell death in neurodegenerative disease are beginning to be “mapped out”. For this Special Issue, the Editors of Brain Sciences welcome the submission of original research manuscripts and reviews that focus on how oxidative stress and alterations in mitochondrial dynamics, structure/function and impaired quality control mechanisms interplay to contribute to the progression of neurodegenerative diseases. Reviews that focus on recent advances in the development of “mito-protective therapies” to reverse mitochondrial dysfunction and neurodegeneration are also welcome.
Dr. Ruben K. Dagda
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondrial dynamics
- mitochondrial import
- mitochondrial biogenesis
- mitophagy
- mitochondrial trafficking
- bioenergetics
- oxidative stress
- neurotrophic signalling
- neurodegeneration
