Non-Motor Deficit in Locked-In Syndrome
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (10 December 2019) | Viewed by 212
Special Issue Editor
Special Issue Information
Dear Colleagues,
Locked-in syndrome (LIS) is considered the most extreme form of motor entrapment with a non-progressive clinical course, and the most common cause of this condition is ischemia of the ventral portion of the pons. This Special Issue aims to provide a forum for discussion of the non-motor deficits of this syndrome (NMD-LIS). In recent years, we have studied a number of NMD-LIS cases, where many of them have been extremely heterogeneous: from pathological laughing and crying to (mostly visual) hallucinations, the almost constant sensation of falling into a void, and that of moving while remaining still. We have also shown impairment in the recognition of emotions on the faces of others, which is more marked towards “negative” emotions. We have associated neurophysiological and neuroradiological studies to neuropsychological tests, finding cortical thickness anomalies in the areas most associated with motor imagery, combined with marked impairment in the execution of tasks more apparently connected with the so-called “embodied cognition”.
I am convinced that NMD-LIS are interesting, both from a clinical point of view and for neuroscience in general, and hope that this Special Issue represents a first step toward sharing both points of view.
Our hypothesis regarding pathogenesis is grounded upon cerebellar deafferentation from the telencephalic cortex.
Dr. Marco Sarà
Guest Editor
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Keywords
- locked-in syndrome
- motor entrapment
- embodied cognition
- self-reported quality of life
- delusions
- hallucinations
- motor hallucinations
- pathological laughter and crying syndrome
- recognition of emotions
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