Novel Understandings of Huntington’s Disease
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 17 April 2026 | Viewed by 9
Special Issue Editor
Interests: drug development in Huntington’s disease; biomarker discovery in neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Huntington’s Disease (HD) is a genetic neurodegenerative disease. The CAG expansion on chromosome 4 in the huntingtin gene was well described in 1993. Since that time, there have been many discoveries in the genetics, epigenetics, clinical manifestations and treatment of HD. This issue will highlight recent developments in our understanding of various biomarkers in HD. Topics will include an update on genetics and epigenetic influences such as somatic expansion, histone modification and the role and function of huntingtin. Clinical trials are more reliant on novel imaging techniques and findings for screening and outcomes. There will be a discussion of a novel research tool, the HD Integrated Staging Scale, as used in research. Assessing cognition in HD has been a core clinical and research need, and insights beyond traditional measures will be discussed. We are soliciting review papers that bring our genetic, imaging and clinical understanding of HD into the present.
Dr. Samuel Frank
Guest Editor
Manuscript Submission Information
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Keywords
- Huntington’s disease
- biomarkers in HD
- genetic modifiers in HD
- MRI in HD
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