Assessment and Rehabilitation of Cognitive Function in Neurological Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 74

Special Issue Editor


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Guest Editor
Neurology Department, HUB-Hôpital Erasme, Brussels, Belgium
Interests: functional connectivity; stroke; cerebellar ataxia

Special Issue Information

Dear Colleagues,

Post-stroke cognitive impairment (PSCI) affects nearly half of stroke survivors, yet the mechanisms that drive it remain elusive. Beyond direct cortical injury, diaschisis—remote functional depression following focal damage—may play a pivotal role. Recent studies have highlighted the contribution of thalamic, hippocampal, and cerebellar diaschisis to PSCI, particularly after anterior circulation stroke, where these regions are structurally intact but disconnected from cortical networks.

Insights from cerebellar ataxias underscore the cognitive role of cerebellar posterior lobes, which co-evolved with the prefrontal cortex and maintain dense anatomical and functional connectivity to executive networks. Lesions involving cerebellar posterior lobes are associated with cognitive impairment and prefrontal diaschisis, while neuromodulation studies begin to target these circuits therapeutically.

We especially welcome translational work bridging diaschisis models with clinical rehabilitation, and studies applying frameworks from neurodegenerative or developmental disorders to cerebrovascular disease.

Dr. Gilles Naeije
Guest Editor

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Keywords

  • post-stroke cognitive impairment
  • diaschisis
  • cerebellum
  • cortico-cerebellar connectivity
  • neuromodulation
  • transcranial cerebellar stimulation
  • cognitive rehabilitation
  • functional connectivity

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Published Papers (1 paper)

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8 pages, 351 KiB  
Brief Report
Screening for Post-Stroke Cognitive Impairment in Sub-Saharan Africa: A Good IDEA?
by Fode Abass Cissé, Yannick Fogoum Fogang, Male Dore and Gilles Naeije
Brain Sci. 2025, 15(6), 543; https://doi.org/10.3390/brainsci15060543 - 22 May 2025
Abstract
Background: Post-stroke cognitive impairment (PSCI) remains under-recognized in Sub-Saharan Africa (SSA), in part due to the lack of validated cognitive screening tools adapted to low-literacy populations. We aimed to validate the Identification of Dementia in Elderly Africans (IDEA) cognitive screen in SSA and [...] Read more.
Background: Post-stroke cognitive impairment (PSCI) remains under-recognized in Sub-Saharan Africa (SSA), in part due to the lack of validated cognitive screening tools adapted to low-literacy populations. We aimed to validate the Identification of Dementia in Elderly Africans (IDEA) cognitive screen in SSA and assess its utility for detecting PSCI in Guinea and Cameroon. Methods: Normative IDEA scores were derived from a control cohort of healthy older adults in Conakry (Guinea) and Bafoussam (Cameroon). The tool was then applied to consecutive stroke patients from the same hospitals within one month of stroke onset. Demographic, clinical, and vascular risk profiles were collected. Between-group comparisons were performed using Welch’s t-tests and chi-square tests. Results: Among 91 healthy controls (median age: 64), the mean IDEA score was 12 ± 2.4. A cut-off of ≤7 (2 standard deviations below the mean) was defined for cognitive impairment. Among 111 stroke patients (median age: 65; mean NIHSS: 9.9 ± 5.8), the mean IDEA score was 9.6 ± 3.2, and 31 patients (28%) had scores ≤ 7. Stroke patients had significantly higher rates of hypertension and diabetes compared to controls. Conclusions: The IDEA screen appears to be a feasible and effective tool for detecting PSCI in SSA clinical settings. The 28% prevalence of cognitive impairment aligns with data from high-income countries, supporting the broader use of the IDEA to strengthen cognitive care pathways in SSA stroke populations. Full article
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