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Brain Sciences
Special Issues
Novel Neuroimaging of Neurological and Psychiatric Disorders
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Novel Neuroimaging of Neurological and Psychiatric Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (30 May 2025) | Viewed by 3151

Special Issue Editor

Dr. Darrin J. Lee

E-Mail Website
Guest Editor
1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
2. USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Interests: deep brain stimulation; electrophysiology; neuromodulation; Parkinson’s disease; essential tremor; dystonia; epilepsy; depression; Alzheimer’s disease; obsessive-compulsive disorder
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neuroimaging facilitates the diagnosis of neurological and psychiatric disorders. The field has made remarkable advances over the past few years, fueled by a variety of converging technical and data developments. Treatment typically involves a multidisciplinary technique used for addressing each neurological symptom and underlying psychological factor via a mixture of medical management, psychotherapy, and supportive interventions. Recent advances in neuroimaging and a deeper exploration of its epidemiology, pathophysiology, and clinical presentation have shed new light on this disorder.

Neuroimaging provides a window to observe “in vivo” brain structure and function. Functional neuroimaging, such as functional magnetic resonance imaging, positron emission tomography, and single photon emission tomography, may facilitate the identification of therapeutic targets, optimize drug therapy, and potentially inform clinical trials.

For this Special Issue, we welcome all papers related to the application of neuroimaging techniques for the treatment of all kinds of neurological disorders. We encourage the submission of the following types of papers: original papers, comprehensive reviews, short reports, communications, perspectives, opinions, clinical trials, etc.

Dr. Darrin J. Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimaging
  • diagnosis
  • treatment
  • psychiatric diseases
  • brain structure

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Published Papers (1 paper)

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Review

37 pages, 2371 KB  
Review
Visual Neurorestoration: An Expert Review of Current Strategies for Restoring Vision in Humans
by Jonathon Cavaleri, Michelle Lin, Kevin Wu, Zachary Gilbert, Connie Huang, Yu Tung Lo, Vahini Garimella, Jonathan C. Dallas, Robert G. Briggs, Austin J. Borja, Jae Eun Lee, Patrick R. Ng, Kimberly K. Gokoffski and Darrin J. Lee
Brain Sci. 2025, 15(11), 1170; https://doi.org/10.3390/brainsci15111170 - 30 Oct 2025
Viewed by 2724
Abstract
Visual impairment impacts nearly half a billion people globally. Corrective glasses, artificial lens replacement, and medical management have markedly improved the management of diseases inherent to the eye, such as refractive errors, cataracts, and glaucoma. However, therapeutic strategies for retinopathies, optic nerve damage, [...] Read more.
Visual impairment impacts nearly half a billion people globally. Corrective glasses, artificial lens replacement, and medical management have markedly improved the management of diseases inherent to the eye, such as refractive errors, cataracts, and glaucoma. However, therapeutic strategies for retinopathies, optic nerve damage, and distal optic pathways remain limited. The complex optic apparatus comprises multiple neural structures that transmit information from the retina to the diencephalon to the cortex. Over the last few decades, innovations have emerged to address the loss of function at each step of this pathway. Given the retina’s lack of regenerative potential, novel treatment options have focused on replacing lost retinal cell types through cellular replacement with stem cells, restoring lost gene function with genetic engineering, and imparting new light sensation capabilities with optogenetics. Additionally, retinal neuroprosthetics have shown efficacy in restoring functional vision, and neuroprosthetic devices targeting the optic nerve, thalamus, and cortex are in early stages of development. Non-invasive neuromodulation has also shown some promise in modulating the visual cortex. Recently, the first in-human whole-eye transplant was performed. While functional vision was not restored, the feasibility of such a transplant with viable tissue graft at one year was demonstrated. Subsequent studies are now focused on guidance cues for axonal regeneration past the graft site to reach the lateral geniculate nucleus. Although the methods discussed above have shown promise individually, improvements in vision have been modest at best. Achieving the goal of restoration of functional vision will clearly require further development of cellular therapies, genetic engineering, transplantation, and neuromodulation. A concerted multidisciplinary effort involving scientists, engineers, ophthalmologists, neurosurgeons, and reconstructive surgeons will be necessary to restore vision for patients with vision loss from these challenging pathologies. In this expert review article, we describe the current literature in visual neurorestoration with respect to cellular therapeutics, genetic therapies, optogenetics, neuroprosthetics, non-invasive neuromodulation, and whole-eye transplant. Full article
(This article belongs to the Special Issue Novel Neuroimaging of Neurological and Psychiatric Disorders)
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