Low-Cost and Miniaturized Biosensors for Homecare Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (10 August 2021) | Viewed by 2857

Special Issue Editors

School of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
Interests: biological sensing based on multi-gate silicon field-effect transistors and electrochemical impedance spectroscopy; field-effect transistors based on the electrostatically-formed nanowire; light trapping based on arrays of nanostructures; photovoltaics; photocarrier collection; omnidirectional broadband absorption of solar radiation
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Department of Physical Chemistry, Israel Institute for Biological Research, Ness Ziona, Isrel
Interests: chemical and biological sensing; analytical techniques - IR spectroscopy (FTIR, Raman, photo-acoustic); ion mobility spectrometry; electrochemical and electronic sensors; sampling techniques; ambient desorption-ionization; low temperature plasma; spray ionization techniques; sensor decision making systems; chemometrics; machine learning

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Guest Editor
Environmental Physics and Solar Energy Department, Ben-Gurion University of the Negev, Beer-Sheva 653, Israel
Interests: molecular interfaces; hybrid devices; nanowires; 2D materials; charge transfer; green energy; surface functionalization & characterization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The ever-growing need for improved medical diagnostics has expanded during the recent years to applications of point of care diagnostics and at home, self-use diagnostics. The recent outbreak of the COVID-19 pandemic has crystallized the emerging need for low-cost self-use diagnostic capabilities for homecare applications. A corollary of the COVID-19 pandemic is the global tendency of both physicians and patients to avoid patients visiting medical centers unless unavoidable, which, together with the increase in self-care and wellness, scales up the need for home care medicine and particularly homecare diagnostics. The future of homecare diagnostics will be based on research and development in the fields of sampling, data acquisition technology, and analysis. The underlying disciplines of these three building blocks include, to name a few, microfluidic and paper-based separation systems for sampling, optical, electrochemical, electronic, and acoustic signal transduction schemes, and informatics, chemometrics, and machine learning for the analysis of the data. Using this toolbox should aim at reaching excellence in performance that is expressed in various parameters such as sensitivity, specificity, versatility (multiplexing), analysis time, size, cost, ease of use, robustness, and more.

In recent years, a tremendous scientific progress has been reported for biosensing based on novel electronic and optical approaches compatible with homecare diagnostics requirements. In the current Special Issue, we are focusing on biosensors as smart analytical diagnostic tools with potential implementation in point-of-care (POC) and homecare applications needed for personalized health care/management. Therefore, we invite authors to publish, in this Special Edition, scientific articles and/or reviews on, but not limited to, the following topics:

  • Novel biosensing applications;
  • Biological sensing technologies for homecare and/or point-of-care (e.g., optical/photonic, electrochemical, electronic, acoustic, MEMS/NEMS);
  • Biosensing approaches: specific/non-specific, labelled/label-free, affinity/activity assays, etc.;
  • Sample preparation and introduction/transport;
  • Informatics, chemometrics, and machine learning for the data analysis;
  • Analog design for biosensors;
  • Lab on a chip (microfluidics, etc.);
  • Surface modifications and surface characterization (chemical, biological, topography, etc.).

Dr. Gil Shalev
Dr. Izhar Ron
Dr. Muhammad Bashouti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

14 pages, 5814 KiB  
Communication
High-Performance Passive Plasma Separation on OSTE Pillar Forest
by Zhiqing Xiao, Lexin Sun, Yuqian Yang, Zitao Feng, Sihan Dai, Hao Yang, Xingwei Zhang, Chia-Lin Sheu and Weijin Guo
Biosensors 2021, 11(10), 355; https://doi.org/10.3390/bios11100355 - 25 Sep 2021
Cited by 4 | Viewed by 2425
Abstract
Plasma separation is of high interest for lateral flow tests using whole blood as sample liquids. Here, we built a passive microfluidic device for plasma separation with high performance. This device was made by blood filtration membrane and off-stoichiometry thiol–ene (OSTE) pillar forest. [...] Read more.
Plasma separation is of high interest for lateral flow tests using whole blood as sample liquids. Here, we built a passive microfluidic device for plasma separation with high performance. This device was made by blood filtration membrane and off-stoichiometry thiol–ene (OSTE) pillar forest. OSTE pillar forest was fabricated by double replica moldings of a laser-cut polymethylmethacrylate (PMMA) mold, which has a uniform microstructure. This device utilized a filtration membrane to separate plasma from whole blood samples and used hydrophilic OSTE pillar forest as the capillary pump to propel the plasma. The device can be used to separate blood plasma with high purity for later use in lateral flow tests. The device can process 45 μL of whole blood in 72 s and achieves a plasma separation yield as high as 60.0%. The protein recovery rate of separated plasma is 85.5%, which is on par with state-of-the-art technologies. This device can be further developed into lateral flow tests for biomarker detection in whole blood. Full article
(This article belongs to the Special Issue Low-Cost and Miniaturized Biosensors for Homecare Diagnostics)
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