Recent Advances in Biosensors for Pharmaceutical Analysis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 3688

Special Issue Editors

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
Interests: biosensors; electronics engineering; microfluidics; medical engineering; chinese materia medica analysis
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Guest Editor
Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang 330115, China
Interests: biosensors; HEMT biosensors for natural active compound discovery; herbal analysis; novel drug development

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Guest Editor
Jiangsu Key Laboratory of Neuropsychiatric Disease, College of Pharmaceutical Science, Suzhou Medical College of Soochow University, Suzhou 215127, China
Interests: organ-on-chip; microfluidics; organoid-on-chip

Special Issue Information

Dear Colleagues,

The rapid development of biosensors has made them a critical tool in pharmaceutical research, drug development, and clinical diagnostics. Their core feature lies in integrating biological recognition elements, such as enzymes, antibodies or DNA, with physical or chemical sensors to achieve real-time, highly sensitive detection of drug molecules and their biological effects. In recent years, advancements in nanotechnology, microelectronics and bioengineering have significantly enhanced the sensitivity, specificity and stability of biosensors, enabling their important role in drug screening, drug quality assessment, drug delivery, pharmacokinetics and toxicological studies. For example, electrochemical biosensors can detect the interaction between drugs and target molecules (such as enzymes, receptors and antibodies) in real time to achieve rapid drug screening. By combining organ chips with biosensors, we can analyze the metabolic pathways and toxicity of drugs in a simulated environment, reducing the use of animal experiments. Implantable biosensors can directly monitor the drug concentration in patients and adjust the drug release according to real-time data to ensure the accuracy of drug release, so as to improve the curative effect and reduce side effects. In the quality control of the drug production process, biosensors can monitor the drug composition, pollutant content and drug concentration in real time, ensuring that the produced drugs meet the quality standards. With ongoing advancements in nanotechnology, bioengineering and information technology, biosensors are expected to see broader application and adoption in the future, playing a more significant role, especially in drug development, clinical applications and personalized medicine.

This Special Issue, entitled "Recent Advances in Biosensors for Pharmaceutical Analysis”, will collect reviews or original research papers on biosensors for pharmaceutical analysis.

Dr. Wuzhen Qi
Dr. Zhixin Wang
Dr. Xiuli Zhang
Guest Editors

Manuscript Submission Information

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Keywords

  • biosensors
  • microfluidics
  • organ-on-chip
  • drug screening
  • drug quality assessment
  • drug delivery
  • pharmacokinetics
  • toxicological studies

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Published Papers (2 papers)

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Review

41 pages, 23754 KB  
Review
Carbon Dot-Based Electrochemical and Optical Sensors for Pharmaceutical Analysis and Point-of-Care Diagnostics
by Ganesh Gollavelli, Chiranjib Patra, Chiranjeevi Korupalli, Manuri Brahmayya and Yong-Chen Ling
Biosensors 2026, 16(5), 246; https://doi.org/10.3390/bios16050246 - 28 Apr 2026
Viewed by 867
Abstract
Because of their special optical and electrochemical characteristics, superior biocompatibility, adjustable surface chemistry, and inexpensive, scalable synthesis, carbon dots (CDs), including carbon quantum dots and graphene quantum dots, have become powerful and adaptable nanomaterials for advanced pharmaceutical analysis and other toxicants. The sensitive [...] Read more.
Because of their special optical and electrochemical characteristics, superior biocompatibility, adjustable surface chemistry, and inexpensive, scalable synthesis, carbon dots (CDs), including carbon quantum dots and graphene quantum dots, have become powerful and adaptable nanomaterials for advanced pharmaceutical analysis and other toxicants. The sensitive and selective detection of active pharmaceutical substances, degradation products, contaminants, biomarkers, and therapeutic medication levels in complex matrices has shown great promise in recent years with CD-based nanobiosensors. The development of various sensing platforms, such as electrochemical, optical, and dual-mode biosensors, as well as integration into microfluidic, paper-based, and wearable point-of-care (POC) devices, is made possible by their intrinsic fluorescence, effective electron transfer capacity, and ease of functionalization. With an emphasis on sensing mechanisms, biorecognition techniques, and analytical performance, this study critically reviews current developments in CD-based nanobio/chemosensors for pharmaceutical analysis. It includes a thorough discussion of important applications in drug development, stability research, therapeutic drug monitoring, and drug quality control. Along with new developments like green synthesis, AI-assisted signal processing, and smart sensing platforms, current issues with reproducibility, standardization, biocompatibility, and regulatory validation are highlighted. Lastly, prospects for the industrial application and clinical translation of CD-based nanobiosensors are discussed. Full article
(This article belongs to the Special Issue Recent Advances in Biosensors for Pharmaceutical Analysis)
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28 pages, 8033 KB  
Review
The Application of Microfluidics in Traditional Chinese Medicine Research
by Shanxi Zhu, Xuanqi Ke, Yayuan Li, Zixuan Shu, Jiale Zheng, Zihan Xue, Wuzhen Qi and Bing Xu
Biosensors 2025, 15(12), 770; https://doi.org/10.3390/bios15120770 - 25 Nov 2025
Viewed by 1866
Abstract
Microfluidics enables precise manipulation of scarce Traditional Chinese Medicine (TCM) samples while accelerating analysis and enhancing sensitivity. Device-level structures explain these gains: staggered herringbone and serpentine mixers overcome low-Reynolds-number constraints to shorten diffusion distances and reduce incubation time; flow-focusing or T-junction droplet generators [...] Read more.
Microfluidics enables precise manipulation of scarce Traditional Chinese Medicine (TCM) samples while accelerating analysis and enhancing sensitivity. Device-level structures explain these gains: staggered herringbone and serpentine mixers overcome low-Reynolds-number constraints to shorten diffusion distances and reduce incubation time; flow-focusing or T-junction droplet generators create one-droplet–one-reaction compartments that suppress cross-talk and support high-throughput screening; “Christmas-tree” gradient generators deliver quantitative dosing landscapes for mechanism-aware assays; micropillar/weir arrays and nanostructured capture surfaces raise surface-to-volume ratios and probe density, improving capture efficiency and limits of detection; porous-membrane, perfused organ-on-a-chip architectures recreate apical–basolateral transport and physiological shear, enabling metabolism-aware pharmacology and predictive toxicology; wax-patterned paper microfluidics (µPADs) use capillary networks for instrument-free metering in field settings; and lab-on-a-disc radial channels/valves exploit centrifugal pumping for parallelised workflows. Framed by key performance indicators—sensitivity (LOD/LOQ), reliability/reproducibility, time-to-result, throughput, sample volume, and sustainability/cost—this review synthesises how such structures translate into value across TCM quality/safety control, toxicology, pharmacology, screening, and delivery. Emphasis on structure–function relationships clarifies where microfluidics most effectively closes gaps between chemical fingerprints and biological potency and indicates practical routes for standardisation and deployment. Full article
(This article belongs to the Special Issue Recent Advances in Biosensors for Pharmaceutical Analysis)
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