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Biosensors
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SPR-Based Biochip
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SPR-Based Biochip

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 5172

Special Issue Editor

Dr. Wenjun Hu

E-Mail Website
Guest Editor
School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: biosensors; SPR; biochip

Special Issue Information

Dear Colleagues,

The sudden outbreak of COVID-19 rapidly developed into a global pandemic, which caused tens of millions of infections and millions of deaths. The importance of detecting methods to prevent the spread of disease has been reaffirmed by the pandemic and the associated social and economic damage. Surface plasmon resonance (SPR) biosensors are known for their high sensitivity, lack of labelled samples, simplicity of operation, and quick and easy detection. The application of new materials in plasmon resonance sensing and 3D complex plasmonic structures created powerful tenability have improved the device sensitivity and quality factors unprecedentedly. Furthermore, the integration of surface plasmon resonance sensors with microfluidics, photonic circuits, and microelectronics permits the realization of comprehensive sensing systems for lab-on-a-chip and mobile applications. The purpose of this topic is to bring together high-quality research articles and reviews on all aspects of SPR chips and their applications in life science and serve as a platform for colleagues to exchange novel ideas in this area.

Dr. Wenjun Hu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plasmon resonance
  • biochip
  • nanophotonics
  • nanomaterials
  • optical imaging
  • spectroscopy

Published Papers (3 papers)

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Research

11 pages, 2986 KiB  
Article
Stabilization of Copper-Based Biochips with Alumina for Biosensing Application
by Nour Beydoun, Yann Niberon, Laurent Arnaud, Julien Proust, Komla Nomenyo, Shuwen Zeng, Gilles Lerondel and Aurelien Bruyant
Biosensors 2022, 12(12), 1132; https://doi.org/10.3390/bios12121132 - 6 Dec 2022
Cited by 1 | Viewed by 1491
Abstract
Surface plasmon resonance devices typically rely on the use of gold-coated surfaces, but the use of more abundant metals is desirable for the long-term development of plasmonic biochips. As a substitute for gold, thin copper films have been deposited on glass coverslips by [...] Read more.
Surface plasmon resonance devices typically rely on the use of gold-coated surfaces, but the use of more abundant metals is desirable for the long-term development of plasmonic biochips. As a substitute for gold, thin copper films have been deposited on glass coverslips by thermal evaporation. As expected, these films immersed in a water solution initially exhibit an intense plasmonic resonance comparable to gold. However, without protection, an angle-resolved optical analysis shows a rapid degradation of the copper, characterized by a continuous angular shift of the plasmonic resonance curve. We show that copper films protected with a thin layer of aluminum oxide of a few nanometers can limit the oxidation rate for a sufficient time to perform some standard measurements. As the process is simple and compatible with the current biochip production technique, such an approach could pave the way for the production of alternative and more sustainable biochips. Full article
(This article belongs to the Special Issue SPR-Based Biochip)
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10 pages, 1974 KiB  
Article
Terahertz Biosensor Based on Mode Coupling between Defect Mode and Optical Tamm State with Dirac Semimetal
by Yuwen Bao, Mengjiao Ren, Chengpeng Ji, Jun Dong, Leyong Jiang and Xiaoyu Dai
Biosensors 2022, 12(11), 1050; https://doi.org/10.3390/bios12111050 - 21 Nov 2022
Cited by 2 | Viewed by 1377
Abstract
Bulk Dirac semimetal (BDS) has emerged as a “3D graphene” material for the development of optical devices in the past few years. In this study, a BDS-based tunable highly sensitive terahertz (THz) biosensor is proposed by using a Dirac semimetal/Bragg reflector multilayer structure. [...] Read more.
Bulk Dirac semimetal (BDS) has emerged as a “3D graphene” material for the development of optical devices in the past few years. In this study, a BDS-based tunable highly sensitive terahertz (THz) biosensor is proposed by using a Dirac semimetal/Bragg reflector multilayer structure. The high sensitivity of the biosensor originates from the sharp Fano resonance peak caused by coupling the Optical Tamm State (OTS) mode and defect mode. Besides, the sensitivity of the proposed structure is sensitive to the Fermi energy of Dirac semimetal and the refractive index of the sensing medium. The maximum sensitivity of 1022°/RIU is obtained by selecting structural and material parameter appropriately, which has certain competitiveness compared to conventional surface plasmon resonance (SPR) sensors. From the standpoint of the fabrication facility and integration, we judged that the BDS-based layered structure has the potential application in biosensor field. Full article
(This article belongs to the Special Issue SPR-Based Biochip)
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11 pages, 1851 KiB  
Communication
Au-Ag Alloy Nanoshuttle Mediated Surface Plasmon Coupling for Enhanced Fluorescence Imaging
by Kai-Xin Xie, Zhao Li, Jia-Hua Fang, Shuo-Hui Cao and Yao-Qun Li
Biosensors 2022, 12(11), 1014; https://doi.org/10.3390/bios12111014 - 13 Nov 2022
Cited by 6 | Viewed by 1471
Abstract
Surface plasmon-coupled emission (SPCE), a novel signal enhancement technology generated by the interactions between surface plasmons and excited fluorophores in close vicinity to metallic film, has shown excellent performance in bioimaging. Variable-angle nanoplasmonic fluorescence microscopy (VANFM), based on an SPCE imaging system, can [...] Read more.
Surface plasmon-coupled emission (SPCE), a novel signal enhancement technology generated by the interactions between surface plasmons and excited fluorophores in close vicinity to metallic film, has shown excellent performance in bioimaging. Variable-angle nanoplasmonic fluorescence microscopy (VANFM), based on an SPCE imaging system, can selectively modulate the imaging depth by controlling the excitation angles. In order to further improve the imaging performance, Au-Ag alloy nanoshuttles were introduced into an Au substrate to mediate the plasmonic properties. Benefiting from the strong localized plasmon effect of the modified SPCE chip, better imaging brightness, signal-to-background ratio and axial resolution for imaging of the cell membrane region were obtained, which fully displays the imaging advantages of SPCE system. Meanwhile, the imaging signal obtained from the critical angle excitation mode was also amplified, which helps to acquire a more visible image of the cell both from near- and far-field in order to comprehensively investigate the cellular interactions. Full article
(This article belongs to the Special Issue SPR-Based Biochip)
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