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Biosensors
Special Issues
Optical Fiber Sensors for Biomedical Application
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Optical Fiber Sensors for Biomedical Application

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 2468

Special Issue Editors

Prof. Dr. A Ping Zhang

E-Mail Website
Guest Editor
Photonics Research Institute, Department of Electrical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong
Interests: optical micro/nano-fabrication; optical fiber devices; micro/nano-photonics; sensors and biochips
Dr. Alexis Mendez

E-Mail Website
Guest Editor
MCH Engineering LLC, Alameda, CA 94501, USA
Interests: fiber optics; fiber optic sensors; fiber Bragg gratings; distributed fiber sensing; FBG sensors

Special Issue Information

Dear Colleagues,

Optical fiber sensors represent a unique type of sensor technology. Their benefits include their small size, immunity to electromagnetic interference, high sensitivity, good chemical resistance, and remote and multiplexing/distributed sensing abilities. They have not only revolutionized high-speed communications by transmitting optical signals at a very low loss level, but have also enabled the development of various sensor technologies for many different applications. One of the emerging and promising applications of optical fiber sensors is in biomedical sensors and devices. For instance, their convenient light delivery and collection abilities have facilitated the development of various optical biosensors for use in rapid testing and diagnosis. Especially with the development of nanofabrication technologies, many novel optical-fiber-based sensors, such as optical fiber-tip plasmonic biosensors and Raman probes, have been developed to detect biomarkers and diagnose diseases in early stages. On the other hand, their miniature size enables the development of novel, minimally invasive tools which can monitor physiological parameters in real time during operations. This is an up-and-coming technology that holds great potential in the areas of biomedical diagnosis and surgery. This Special Issue provides a platform for both the academic community and industry to report and share recent developments and progress within this field.

Prof. Dr. A Ping Zhang
Dr. Alexis Mendez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical fiber sensors
  • optical fiber biosensors
  • plasmonic biosensors
  • biomedical sensors
  • biodetection
  • diagnosis
  • point-of-care
  • surgery
  • healthcare

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Published Papers (1 paper)

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Research

11 pages, 1936 KiB  
Article
Optic Fiber Microsensor Reveals Specific Spatiotemporal Oxygen Uptake Profiles at the Mammalian Ocular Surface
by Qin Sun, Li Ma, Fernando Ferreira, Chelsea Brown, Brian Reid and Min Zhao
Biosensors 2023, 13(2), 245; https://doi.org/10.3390/bios13020245 - 9 Feb 2023
Cited by 1 | Viewed by 1765
Abstract
Oxygen (O2) uptake by cells and tissues is a critical indicator of metabolic demand, changes in microenvironment, and pathophysiology. O2 uptake from the atmosphere accounts for virtually all the O2 consumption in the avascular cornea; however, a detailed spatiotemporal [...] Read more.
Oxygen (O2) uptake by cells and tissues is a critical indicator of metabolic demand, changes in microenvironment, and pathophysiology. O2 uptake from the atmosphere accounts for virtually all the O2 consumption in the avascular cornea; however, a detailed spatiotemporal profile of corneal O2 uptake (COU) remains undetermined. Here, we used a non-invasive self-referencing optical fiber O2 sensor—the scanning micro-optrode technique (SMOT)—to report the O2 partial pressure and flux variations at the ocular surface of rodents and non-human primates. In vivo spatial mapping in mice revealed a distinct COU, characterized by a centripetal gradient with a significantly higher O2 influx at the limbus and conjunctiva regions than at the center of the cornea. This regional COU profile was reproduced ex vivo in freshly enucleated eyes. The centripetal gradient was conserved across the following species analyzed: mice, rats, and rhesus monkeys. In vivo temporal mapping in mice showed a significant increase in the O2 flux in the limbus in the evening compared to other times. Altogether, the data unveiled a conserved centripetal COU profile, which may be associated with the limbal epithelial stem cells residing at the intersection of the limbus and conjunctiva. These physiological observations will serve as a useful baseline for comparative studies with contact lens wear, ocular disease, diabetes, etc. Moreover, the sensor may be applied to understand the responses of the cornea and other tissues to various insults, drugs, or changes in the environment. Full article
(This article belongs to the Special Issue Optical Fiber Sensors for Biomedical Application)
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