2D Materials-Based Biosensors for Diseases Diagnosis

Dear Colleagues,

Since the isolation of graphene in 2004, different types of two-dimensional (2D) materials (e.g., transition metal dichalcogenides, hexagonal boron nitride, graphitic carbon nitride, transition metal oxides, and the recently discovered transition metal carbides and nitrides (MXenes)) have received considerable attention in the design of next-generation nanomedical tools for diagnostic and therapeutic applications. For the early diagnosis of diseases, biosensors are affordable, miniaturized, and easy to use, and enable to on-site detection of the target analyte with minimum or no sample pretreatment. As transduction elements and supporting substrates, 2D materials have been utilized to detect a wide range of chemical and biological analytes. Features like a higher surface-to-volume ratio offer increased analyte-surface binding sites, leading to better modulation of the inherent electronic properties and improving the sensitivity and detection limit for the target analyte. These 2D materials have also been extensively used for bioimaging applications, mainly due to the atomically thin structure, the abundance of chemically active sites, and quantum confinement effect. Additionally, the ultrathin nature of these materials with layered structures and higher surface-to-volume ratio offers significant advantages for the delivery of different therapeutics drugs and proteins.

This Special Issue will be focused on recent advances in novel synthesis, surface functionalization, and their application in a wide range of nanomedical applications. Original research articles, review articles, and short communications are invited. Prospective authors planning to submit an article are encouraged to send a title and short abstract. With the aim of highlighting the recent developments in 2D-materials-based nanomedical tools, the following topics will be explored in this Special Issue.

1. Synthesis of 2D materials and their nanocomposites for biosensing, chemical sensing and bioimaging applications.
2. Green and sustainable 2D materials for diagnostic applications.
3. 2D materials for the delivery of therapeutics.
4. Surface engineering of 2D materials to improve immobilization conditions for proteins.
5. New technological advancements in developments of 2D materials-based electrodes for biosensors.
6. Applications of 2D materials in industrial diagnostics and therapeutic products.
7. 2D-materials-integrated microfluidic devices for health monitoring.
8. Role of 2D materials in the diagnostics of emerging infectious diseases.

Dr. Chandan Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• two-dimensional nanostructures
• synthesis and characterization
• biofunctionalization
• electrochemical biosensors
• graphene oxide
• nanocomposites
• MXenes
• point-of-care diagnostics