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Biosensors
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Application of Functional Nanomaterials in Photo/Electrical Biosensing
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Application of Functional Nanomaterials in Photo/Electrical Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1472

Special Issue Editors

Dr. Yaoguang Wang

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
Interests: electrochemical biosensors; biomarker detection; environmental analysis; nanomaterials; nanozymes; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Guanhui Zhao

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250200, China
Interests: electrochemiluminescence sensing; metal–organic framework materials; biomarker detection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Photo/electrical biosensing analysis technology has received continuous attention from researchers due to its advantages of high sensitivity, good selectivity, fast analytical speed, easy operation, and portability. It has been widely applied in fields such as molecular recognition, disease diagnosis, food safety detection, and environmental monitoring. With the rapid development of science and technology and the increasing demand for detection, continuously improving the detection sensitivity, reproducibility of analytical results, selectivity of analytical methods, and stability of sensing interfaces of photo/electrical biosensing analysis technology remains an important challenge and urgent scientific problem for analytical chemists. Therefore, the development of highly sensitive, reproducible, selective, and stable photo/electrical biosensing analytical technologies, as well as the design and development of photo/electrochemical biosensors with simple operation, low cost, easy miniaturization, and on-site real-time detection, have important scientific value and research significance. This Special Issue will focus on the recent advances in the application of functional nanomaterials in photo/electrical biosensing, especially electrochemical biosensors, electrochemiluminescent biosensors, and photoelectrochemical biosensors. We request submissions of research that helps to advance the applications of nanotechnologies in the field of analytical chemistry.

Dr. Yaoguang Wang
Dr. Guanhui Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensing
  • functional nanomaterials
  • electrochemical biosensor
  • electrochemiluminescent biosensor
  • photoelectrochemical biosensor

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Published Papers (2 papers)

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13 pages, 2158 KiB  
Article
A Smart Nanoprobe for Visually Investigating the Activation Effect of Cyclical DOX Release on the p53 Pathway and Pathway-Related Molecules
by Ping Sun, Chunlei Gao, Zhe Chen, Siyu Wang, Gang Li, Mingming Luan and Yaoguang Wang
Biosensors 2025, 15(6), 383; https://doi.org/10.3390/bios15060383 - 13 Jun 2025
Viewed by 447
Abstract
Developing appropriate methods for real-time in situ investigation of how drugs influence signaling pathways and related biomolecules holds enormous potential for helping to provide an understanding of how anticancer drugs exert their effects. Herein, we report a smart nanoprobe, PDA-MB (DOX)-Pep, constructed on [...] Read more.
Developing appropriate methods for real-time in situ investigation of how drugs influence signaling pathways and related biomolecules holds enormous potential for helping to provide an understanding of how anticancer drugs exert their effects. Herein, we report a smart nanoprobe, PDA-MB (DOX)-Pep, constructed on the basis of polydopamine nanoparticles (PDA NPs) modified with a dense shell of molecular beacon (MB) with embedded doxorubicin (DOX) and peptide, which can respond specifically to miRNA-34a and Caspase-3 targets. Intracellular experiments demonstrated that, in comparison to the control nanoprobe PDA-MB-Pep, the smart nanoprobe could selectively respond to miRNA-34a, facilitating the release of the embedded DOX. The released DOX subsequently activated the p53 pathway, which further upregulated miRNA-34a expression, leading to additional DOX release. This initiated a cyclical process involving the probe’s response to miRNA-34a, DOX release, p53 activation, and miRNA-34a upregulation, ultimately enhancing cell apoptosis and increasing Caspase-3 expression. The designed smart nanoprobe offers a visual approach to explore how anticancer drugs influence signaling pathways and related molecules at the cellular level. Full article
(This article belongs to the Special Issue Application of Functional Nanomaterials in Photo/Electrical Biosensing)
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17 pages, 2881 KiB  
Article
Biological Sensing Using Vertical MoS2-Graphene Heterostructure-Based Field-Effect Transistor Biosensors
by Ying Chen, Nataly Vicente, Tung Pham and Ashok Mulchandani
Biosensors 2025, 15(6), 373; https://doi.org/10.3390/bios15060373 - 10 Jun 2025
Viewed by 695
Abstract
Our study develops two configurations of MoS2 and graphene heterostructures—MoS2 on graphene (MG) and graphene on MoS2 (GM)—to investigate biomolecule sensing in field-effect transistor (FET) biosensors. Leveraging MoS2 and graphene’s distinctive properties, we employ specialized functionalization techniques for each [...] Read more.
Our study develops two configurations of MoS2 and graphene heterostructures—MoS2 on graphene (MG) and graphene on MoS2 (GM)—to investigate biomolecule sensing in field-effect transistor (FET) biosensors. Leveraging MoS2 and graphene’s distinctive properties, we employ specialized functionalization techniques for each configuration: graphene with MoS2 on top uses a silane-based method with triethoxysilylbutyraldehyde (TESBA), and MoS2 with graphene on top utilizes 1-pyrenebutyric acid N-hydroxysuccinimide ester (PBASE). Our research explores the application of MoS2–Graphene heterostructures in biosensors, emphasizing the roles of synthesis, fabrication, and material functionalization in optimizing sensor performance. Through our experimental investigations, we have observed that doping MoS2 and graphene leads to noticeable changes in the Raman spectrum and shifts in transfer curves. Techniques such as XPS, Raman, and AFM have successfully confirmed the biofunctionalization. Transfer curves were instrumental in characterizing the biosensing performance, revealing that GM configurations exhibit higher sensitivity and a lower limit of detection (LOD) compared to MG configurations. We demonstrate that GM heterostructures offer superior sensitivity and specificity in biosensing, highlighting their significant potential to advance biosensor technologies. This research contributes to the field by detailing the creation process of vertical MoS2–graphene heterostructures and evaluating their effectiveness in accurate biomolecule detection, advancing biosensing technology. Full article
(This article belongs to the Special Issue Application of Functional Nanomaterials in Photo/Electrical Biosensing)
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