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Biosensors
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Optical Fiber Biosensor
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Optical Fiber Biosensor

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 10304

Special Issue Editor

Dr. Philippe Velha

E-Mail Website
Guest Editor
Optical Fiber Sensors group of Institute of Mechanical Intelligence, Scuola Superiore Sant'Anna, Pisa, Italy
Interests: silicon photonics; biophotonics; integrated optics; chemical sensors; optical fiber sensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Optical fiber biosensors are analytical devices consisting of a biorecognition element integrated into an optical fiber assembly, which modifies optical signals (intensity, phase, polarization) proportionally to the concentration of the analyte and provides label-free or label-based and real-time detection. Designing, developing, and improving optical fiber biosensors’ attributes is a challenging and important topic for several applications, such as healthcare and disease diagnosis, environmental monitoring, water and food quality monitoring, and drug delivery.

Optical fiber biosensors integrate a biological element, such as an enzyme, antibody, aptamer, whole cell, and tissue, as a biorecognition element. In response to physical or chemical changes created by biorecognition elements, the transduction process induces a change in the light beam, such as absorption, transmission, reflection, refraction, phase, amplitude, frequency, and/or light polarization. Depending on the application, the performance of optical fiber biosensors can be optimized in selectivity, sensitivity, linearity, response time, reproducibility, and stability.

In this context, it is our pleasure to announce this Special Issue entitled “Optical Fiber Biosensors”, where original research and reviews of new fabrication processes, materials, optical fiber integration, and immobilization methods of optical biosensors are cordially invited. We hope that this Special Issue will further encourage and promote scientific contributions by researchers in the biosensors field.

This Special Issue welcomes contributions addressing, but not limited to:

  • Novel interrogation methods for fiber-based biosensors;
  • Surface plasmon (SPR) and localized resonance (LSPR) for biosensing;
  • Biosensors for healthcare applications;
  • Biosensors for aquaculture and environment monitoring;
  • Wearable sensors, devices, and electronics;
  • Lab-on-a-chip;
  • Lab-on-tip;
  • Sensor devices, technology, and applications;
  • Advanced materials for sensing;

Dr. Philippe Velha
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

13 pages, 6807 KiB  
Article
Fiber-Optic-Based System for High-Resolution Monitoring of Stretch in Excised Tissues
by Antonio Velarte, Aranzazu Otin, Pablo Giménez-Gómez, Xavier Muñoz-Berbel and Esther Pueyo
Biosensors 2023, 13(10), 900; https://doi.org/10.3390/bios13100900 - 22 Sep 2023
Cited by 2 | Viewed by 1770
Abstract
Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised [...] Read more.
Cardiovascular diseases cause a high number of deaths nowadays. To improve these statistics, new strategies to better understand the electrical and mechanical abnormalities underlying them are urgently required. This study focuses on the development of a sensor to measure tissue stretch in excised tissues, enabling improved knowledge of biomechanical properties and allowing greater control in real time. A system made of biocompatible materials is described, which is based on two cantilevered platforms that integrate an optical fiber inside them to quantify the amount of stretch the tissues are exposed to with a precision of μm. The operating principle of the sensor is based on the variation of the optical path with the movement of the platforms onto which the samples are fixed. The conducted tests highlight that this system, based on a simple topology and technology, is capable of achieving the desired purpose (a resolution of ∼1 μm), enabling the tissue to be bathed in any medium within the system. Full article
(This article belongs to the Special Issue Optical Fiber Biosensor)
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12 pages, 2430 KiB  
Article
Fabry–Perot Interferometric Fiber-Optic Sensor for Rapid and Accurate Thrombus Detection
by Marjan Ghasemi, Jeongmin Oh, Sunghoon Jeong, Mingyu Lee, Saeed Bohlooli Darian, Kyunghwan Oh and Jun Ki Kim
Biosensors 2023, 13(8), 817; https://doi.org/10.3390/bios13080817 - 15 Aug 2023
Cited by 8 | Viewed by 2729
Abstract
We present a fiber-optic sensor based on the principles of a Fabry–Perot interferometer (FPI), which promptly, sensitively, and precisely detects blood clot formation. This sensor has two types of sensor tips; the first was crafted by splicing a tapered fiber into a single-mode [...] Read more.
We present a fiber-optic sensor based on the principles of a Fabry–Perot interferometer (FPI), which promptly, sensitively, and precisely detects blood clot formation. This sensor has two types of sensor tips; the first was crafted by splicing a tapered fiber into a single-mode fiber (SMF), where fine-tuning was achieved by adjusting the tapered diameter and length. The second type is an ultra-compact blood FPI situated on the core of a single-mode fiber. The sensor performance was evaluated via clot-formation-indicating spectrum shifts induced by the varied quantities of a thrombin reagent introduced into the blood. The most remarkable spectral sensitivity of the micro-tip fiber type was approximately 7 nm/μL, with a power sensitivity of 4.1 dB/μL, obtained with a taper fiber diameter and length of 55 and 300 μm, respectively. For the SMF type, spectral sensitivity was observed to be 8.7 nm/μL, with an optical power sensitivity of 0.4 dB/μL. This pioneering fiber-optic thrombosis sensor has the potential for in situ applications, healthcare, medical monitoring, harsh environments, and chemical and biological sensing. The study underscores the scope of optical technology in thrombus detection, establishing a platform for future medical research and application. Full article
(This article belongs to the Special Issue Optical Fiber Biosensor)
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19 pages, 4347 KiB  
Article
Design Considerations of an ITO-Coated U-Shaped Fiber Optic LMR Biosensor for the Detection of Antibiotic Ciprofloxacin
by Vikas and Paola Saccomandi
Biosensors 2023, 13(3), 362; https://doi.org/10.3390/bios13030362 - 9 Mar 2023
Cited by 11 | Viewed by 2625
Abstract
The extensive use of antibiotics has become a serious concern due to certain deficiencies in wastewater facilities, their resistance to removal, and their toxic effects on the natural environment. Therefore, substantial attention has been given to the detection of antibiotics because of their [...] Read more.
The extensive use of antibiotics has become a serious concern due to certain deficiencies in wastewater facilities, their resistance to removal, and their toxic effects on the natural environment. Therefore, substantial attention has been given to the detection of antibiotics because of their potential detriment to the ecosystem and human health. In the present study, a novel design of indium tin oxide (ITO) coated U-shaped fiber optic lossy mode resonance (LMR) biosensor is presented for the sensitive detection of the antibiotic ciprofloxacin (CIP). The performance of the designed U-shaped LMR sensor is characterized in terms of its sensitivity, full width at half maximum (FWHM), the figure of merit (FOM), and the limit of detection (LOD). For the proposed U-shaped LMR sensing probe, the various crucial factors such as the thickness (d) of the ITO layer, sensing region length (L), and bending radius (R) are optimized. The thickness of the ITO layer is optimized in such a way that two LMR curves are observed in the transmission spectrum and, thereafter, the performance parameters are evaluated for each LMR. It is observed that the designed U-shaped LMR sensor with optimized parameters shows an approximately seven-fold enhancement in sensitivity compared to the straight-core fiber optic LMR sensor. The numerical results revealed that the designed U-shaped fiber optic LMR biosensor can provide a maximum sensitivity of 17,209.9 nm/RIU with the highest FOM of 91.42 RIU−1, and LOD of 6.3 × 10−5 RIU for the detection of CIP hydrochloride in the concentration range of 0.001 to 0.029 mol∙dm−3. Thus, it is believed that the designed LMR biosensor can practically explore its potential use in environmental monitoring and biomedical applications and hence, opens a new window of opportunity for the researchers working in the field of U-shaped fiber optic LMR biosensing. Full article
(This article belongs to the Special Issue Optical Fiber Biosensor)
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15 pages, 3795 KiB  
Article
Capabilities of Double-Resonance LPG and SPR Methods for Hypersensitive Detection of SARS-CoV-2 Structural Proteins: A Comparative Study
by Tinko Eftimov, Petia Genova-Kalou, Georgi Dyankov, Wojtek J. Bock, Vihar Mankov, Sanaz Shoar Ghaffari, Petar Veselinov, Alla Arapova and Somayeh Makouei
Biosensors 2023, 13(3), 318; https://doi.org/10.3390/bios13030318 - 24 Feb 2023
Cited by 7 | Viewed by 2516
Abstract
The danger of the emergence of new viral diseases and their rapid spread demands apparatuses for continuous rapid monitoring in real time. This requires the creation of new bioanalytical methods that overcome the shortcomings of existing ones and are applicable for point-of-care diagnostics. [...] Read more.
The danger of the emergence of new viral diseases and their rapid spread demands apparatuses for continuous rapid monitoring in real time. This requires the creation of new bioanalytical methods that overcome the shortcomings of existing ones and are applicable for point-of-care diagnostics. For this purpose, a variety of biosensors have been developed and tested in proof-of-concept studies, but none of them have been introduced for commercial use so far. Given the importance of the problem, in this study, long-period grating (LPG) and surface plasmon resonance (SPR) biosensors, based on antibody detection, were examined, and their capabilities for SARS-CoV-2 structural proteins detection were established. Supersensitive detections of structural proteins in the order of several femtomoles were achieved by the LPG method, while the SPR method demonstrated a sensitivity of about one hundred femtomoles. The studied biosensors are compatible in sensitivity with ELISA and rapid antigen tests but, in contrast, they are quantitative, which makes them applicable for acute SARS-CoV-2 infection detection, especially during the early stages of viral replication. Full article
(This article belongs to the Special Issue Optical Fiber Biosensor)
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