Advances in CRISPR/Cas-Based Biosensors
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 235
Special Issue Editors
Interests: biomaterials; biosensors; CRISPR biosensing
Special Issue Information
Dear Colleagues,
CRISPR/Cas systems have emerged as a transformative molecular toolkit for biosensing, enabling highly sensitive, specific, and programmable detection of nucleic acids, proteins, small molecules, and chemical signals. Beyond their original genome-editing function, diverse CRISPR/Cas effectors—including Cas12, Cas13, Cas14, and emerging compact and engineered variants—have been repurposed into powerful biosensing platforms through collateral cleavage, signal amplification, and structural engineering strategies.
This Special Issue, “Advances in CRISPR/Cas-Based Biosensors”, aims to showcase recent conceptual, technological, and translational advances in CRISPR-enabled biosensing. Topics of interest include novel Cas effectors and engineered variants; innovative reporter designs and signal transduction mechanisms; amplification-free and autocatalytic sensing strategies; integration with microfluidics, nanomaterials, and point-of-care devices; and emerging applications in clinical diagnostics, infectious disease detection, environmental monitoring, and food safety.
By bringing together original research articles, communications, and critical reviews, this Special Issue seeks to provide a timely and comprehensive overview of the rapidly evolving CRISPR biosensing landscape, highlight persistent technical challenges, and identify future directions for real-world deployment and commercialization of CRISPR-based diagnostic technologies.
We warmly invite researchers from both academia and industry to contribute their latest findings to this Special Issue.
Dr. Fei Deng
Dr. Mei Yang
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- CRISPR/cas biosensors
- Cas12 and Cas13 diagnostics
- programmable nucleases
- nucleic acid detection
- amplification-free biosensing
- point-of-care diagnostics
- nanomaterial-assisted biosensors
- molecular diagnostics
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