Bioactive Molecules against Aging: Organism-, Cell-, and Mitochondria-Based Approaches

Dear Colleagues,

Aging, together with the pathologies that are often associated with it, such as cancer and neurodegenerative diseases, is undoubtedly one of the aspects of human health that mostly impact modern society, both at the social and economic levels worldwide. It is estimated that by the end of this decade, 1 out of 6 people will be older than 60. The scientific community is concerned about the effects of aging on the human body and cognitive capacity and is putting major efforts towards molecular understanding as well as the prevention of the physical and psychological decline associated with age. However, since the process of aging involves a multifaceted interaction of biological events at both the organism and subcellular levels (organ failure, sarcopenia, reduced regeneration, neurological impairment, mitochondrial dysfunction, defective autophagy, and oxidative stress), its comprehension and tackling are particularly complex. Small molecules and bioactive compounds, especially those of natural origin, might help slow down and prevent some of the age-associated physical and cognitive deterioration. This Special Issue is meant to collect the latest findings and reviews on the possible use of bioactive molecules and natural compounds to promote healthy aging and combat age-related pathologies at multiple levels, from subcellular to tissue and whole organism. Original research articles as well as reviews will be welcome.

We are looking forward to receiving your valuable contribution to this Special Issue.

For any additional information or query, do not hesitate to contact us.

Sincerely,

Dr. Giorgia Pallafacchina
Dr. Lucia Biasutto
Guest Editors

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