Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.3
5.5
Journals
Biomolecules
Special Issues
Bioactive Glasses for Biomedical Applications
share announcement

Bioactive Glasses for Biomedical Applications

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological and Bio- Materials".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3623

Special Issue Editor

Dr. Jonathan Massera

E-Mail Website
Guest Editor
Laboratory of Biomaterials and Tissue Engineering, Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland
Interests: biomaterials; bioceramics; bioactive glasses; biocomposites; hybrids; functional biomaterials; cell/materials interactions; protein/materials interactions

Special Issue Information

Dear Colleagues,

Bioactive glasses are a special class of bioceramics which have gained tremendous attention since their discovery by L.L. Hench. Bioactive glasses are used commercially in a broad range of biomedical applications, ranging from bone to skin regeneration. Recently, researchers have focused on further extending the applicability of bioactive glasses in the medical field by: 1) boosting the glasses’ natural osteogenic, angiogenic, and antimicrobial properties through the grafting of biomolecules; 2) developing 3D scaffolds with properties amenable to their use in load-bearing applications; and 3) as part of biocomposites or hybrid biomaterials. This list is, of course, not exhaustive, and other axes of research are also ongoing.

The goal of this Special Issue is to attract original research articles, reviews, or communications that will extend, for example, 1) current knowledge of bioactive glass (powder, bulk, or scaffold) and its interaction with cells and/or proteins, 2) our understanding of the impact of the glass surface physico-chemistry on the grafting of biomolecules, 3) the design of scaffolds (pure glass or composites/hybrids) enabling their use in load-bearing applications, and 4) our knowledge of the impact of ion release from pure bioactive glasses, composites, or hybrids on cell fate.

Dr. Jonathan Massera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive glasses
  • composites
  • hybrids
  • scaffolds
  • cells
  • in vitro
  • in vivo

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 4630 KiB  
Article
New Generation of Hybrid Materials Based on Gelatin and Bioactive Glass Particles for Bone Tissue Regeneration
by Amel Houaoui, Agata Szczodra, Mari Lallukka, Lamia El-Guermah, Remy Agniel, Emmanuel Pauthe, Jonathan Massera and Michel Boissiere
Biomolecules 2021, 11(3), 444; https://doi.org/10.3390/biom11030444 - 17 Mar 2021
Cited by 12 | Viewed by 2721
Abstract
Hybrid scaffolds based on bioactive glass (BAG) particles (<38 µm), covalently linked to gelatin (G*) using 3-glycidoxypropyltrimethoxysilane (GPTMS), have been studied for bone bioengineering. In this study, two glass compositions (13-93 and 13-93B20 (where 20% of the SiO2 was replaced with B [...] Read more.
Hybrid scaffolds based on bioactive glass (BAG) particles (<38 µm), covalently linked to gelatin (G*) using 3-glycidoxypropyltrimethoxysilane (GPTMS), have been studied for bone bioengineering. In this study, two glass compositions (13-93 and 13-93B20 (where 20% of the SiO2 was replaced with B2O3)) were introduced in the gelatin matrix. The Cfactor (gelatin/GPTMS molar ratio) was kept constant at 500. The hybrids obtained were found to be stable at 37 °C in solution, the condition in which pure gelatin is liquid. All hybrids were characterized by in vitro dissolution in Tris(hydroxymethyl)aminomethane (TRIS) solution (for up to 4 weeks) and Simulated Body Fluid (SBF) (for up to 2 weeks). Samples processed with 13-93B20 exhibited faster initial dissolution and significantly faster precipitation of a hydroxyapatite (HA) layer. The faster ion release and HA precipitation recorded from the G*/13-93B20 samples are attributable to the higher reactivity of borosilicate compared to silicate glass. The MC3T3-E1 cell behavior in direct contact with the hybrids was investigated, showing that the cells were able to proliferate and spread on the developed biomaterials. Tailoring the glass composition allows us to better control the material’s dissolution, biodegradability, and bioactivity. Bioactive (especially with 13-93B20 BAG) and biocompatible, the hybrids are promising for bone application. Full article
(This article belongs to the Special Issue Bioactive Glasses for Biomedical Applications)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop