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Special Issue "DNA Polymerases: From the Maintenance of Genetic Information to Applications in Biotechnology and Biomedicine"
Deadline for manuscript submissions: 1 May 2020.
Interests: DNA replication, DNA repair, DNA polymerases, DNA amplification, DNA priming, protein engineering, translesion synthesis, genotoxic agents, DNA virus, transposon
Many applications with fundamental importance in modern molecular biology and biomedicine, including polymerase chain reaction (PCR) and whole genome DNA amplification (WGA), as well as some of the state-of-the-art DNA sequencing technologies, would not be feasible without the advances made in characterizing the DNA polymerases (DNAPs) during the last 60 years. Furthermore, the development of WGA at the single-cell and single-molecule level has contributed to some of the most recent breakthroughs in our knowledge of different complex biological systems—from microbial ecosystems, shedding light into microbial dark matter, to human disease, enhancing the sensitivity to detect genetic variants and mutation profiles of individual cells in a tissue or tumor, as well as changing the paradigms in the early diagnosis of cancer and genetic diseases with non-invasive genetic tests. Furthermore, beyond biotechnology applications, DNAPs are the enzymes responsible for preserving genetic information by replicating and repairing nucleic acid molecules in the cells. In the last years, novel developments and experimental approaches have led to a reevaluation of several accepted mechanisms, and have changed many paradigms in the DNA replication and repair field. This Special Issue will cover new advances on the structure, function, and biological role of DNA polymerases, both well-characterized and new, previously overlooked members with unexpected features, including AEPs, like bacterial LigD or PrimPols.
Dr. Modesto Redrejo Rodriguez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA polymerase
- DNA replication
- DNA repair
- DNA amplification