Molecular Mechanisms of Life-Extending Biomolecules and Interventions with Medical and Technological Implications

Dear Colleagues,

This Special Issue aims to overview our current understanding of biomolecules and life-extending interventions, past studies on model systems having identified life-extending genes, biomolecules and interventions able to extend the lifespan and stress resistance. However, how life-extending biomolecules and interventions work has yet to be adequately explored. In humans, genetic meta-analyses have identified genes associated with genetic signatures of people with extreme longevity, potentially capable of being shared with a wide variety of neurological and age-related comorbidities (Vahdati Nia et al., 2017, Front Genet. 12;8:55. doi: 10.3389/fgene.2017.00055). The genes are involved in the metabolism relevant to nutrients (lipid, amino acids, and carbohydrates), enzymes (e.g., Le et al., 2021, Int J Mol Sci. 2021 22(24):13178. doi: 10.3390/ijms222413178) and associated age-related comorbidities, as well as being involved in lipoprotein metabolism, hemostasis, and neural and immune systems. This Special Issue emphasizes, but is not limited to, genes, biomolecules, metabolism and age-related comorbidities, especially with immediate medical relevance and cutting-edge technologies, including artificial intelligence. I would like to clarify the differences between aging (i.e., causes) and age-related diseases (i.e., outcomes), as well as how each manuscript may fit them.

Prof. Dr. Shin Murakami
Guest Editor

Manuscript Submission Information

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• biomolecules
• genes
• molecular and metabolic mechanisms
• model systems
• humans