Cytoskeleton Structure and Dynamics in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 2482

Special Issue Editors


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Guest Editor
Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99163, USA
Interests: regulation of actin dynamics by actin-binding proteins; protein structure and protein-protein interactions; protein engineering; circular dichroism

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Guest Editor
PhysioLab, University of Florence, 50019 Sesto Fiorentino, FI, Italy
Interests: single cell mechanics; mechanics of motor and cytoskeletal proteins; mechanics and energetics of motor proteins in vitro and in situ; force spectroscopy; optical tweezers; AFM; confocal microscope; TIRF

Special Issue Information

Dear Colleagues,

The mechanical properties of a cell are determined by the dynamics of the cytoskeleton and membrane–cytoskeleton associations. These also play a crucial role in cellular shape, morphology changes, and mechanical signal transduction in living cells. Cells are able to contract, move, invade, and undergo processes like tissue regeneration and cellular transformation due to the organization and rearrangement of the cytoskeleton. In this Special Issue of Biomolecules, we invite contributions, in the form of original research articles and reviews, related to the theme “cytoskeleton structure and dynamics in health and disease”. 

Articles that focus on functional and structural aspects from cellular or molecular perspectives are particularly welcome. The topics of interest include, but are not limited to, the following:

  • Structural and functional aspects of cytoskeletal components.
  • Cytoskeleton during the development of specialized cellular domains (e.g., axons).
  • Cytoskeleton in cell division and cell migration.
  • Cytoskeletal changes in cellular transformation and cancer.
  • Cytoskeleton in muscle cells.
  • Cytoskeleton and mechano-transduction.

Dr. Alla S. S. Kostyukova
Dr. Pasquale Bianco
Guest Editors

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Keywords

  • actin
  • myosin
  • cytoskeleton
  • membrane-cytoskeleton associations
  • mechanotransduction
  • cytokinesis
  • nuclear cytoskeleton
  • contractile systems
  • cell motility
  • cell morphogenesis
  • cell adhesions
  • signal transduction
  • cytoskeleton structure and dynamics
  • microtubules, actin filaments
  • intermediate filaments organization

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Published Papers (1 paper)

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Review

20 pages, 2267 KiB  
Review
SEPT9_i1 and Septin Dynamics in Oncogenesis and Cancer Treatment
by Piotr Jędrzejczak, Kamil Saramowicz, Justyna Kuś, Julia Barczuk, Wioletta Rozpędek-Kamińska, Natalia Siwecka, Grzegorz Galita, Wojciech Wiese and Ireneusz Majsterek
Biomolecules 2024, 14(9), 1194; https://doi.org/10.3390/biom14091194 - 22 Sep 2024
Cited by 1 | Viewed by 2002
Abstract
Despite significant advancements in the field of oncology, cancers still pose one of the greatest challenges of modern healthcare. Given the cytoskeleton’s pivotal role in regulating mechanisms critical to cancer development, further studies of the cytoskeletal elements could yield new practical applications. Septins [...] Read more.
Despite significant advancements in the field of oncology, cancers still pose one of the greatest challenges of modern healthcare. Given the cytoskeleton’s pivotal role in regulating mechanisms critical to cancer development, further studies of the cytoskeletal elements could yield new practical applications. Septins represent a group of relatively well-conserved GTP-binding proteins that constitute the fourth component of the cytoskeleton. Septin 9 (SEPT9) has been linked to a diverse spectrum of malignancies and appears to be the most notable septin member in that category. SEPT9 constitutes a biomarker of colorectal cancer (CRC) and has been positively correlated with a high clinical stage in breast cancer, cervical cancer, and head and neck squamous cell carcinoma. SEPT9_i1 represents the most extensively studied isoform of SEPT9, which substantially contributes to carcinogenesis, metastasis, and treatment resistance. Nevertheless, the mechanistic basis of SEPT9_i1 oncogenicity remains to be fully elucidated. In this review, we highlight SEPT9’s and SEPT9_i1’s structures and interactions with Hypoxia Inducible Factor α (HIF-1 α) and C-Jun N-Terminal Kinase (JNK), as well as discuss SEPT9_i1’s contribution to aneuploidy, cell invasiveness, and taxane resistance—key phenomena in the progression of malignancies. Finally, we emphasize forchlorfenuron and other septin inhibitors as potential chemotherapeutics and migrastatics. Full article
(This article belongs to the Special Issue Cytoskeleton Structure and Dynamics in Health and Disease)
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