Inorganic Polyphosphate: A Multifaceted Biomolecule

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 2755

Special Issue Editor


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Guest Editor
Department of Biomedicine, Biotechnology, and Public Health, Medical School, Universidad de Cadiz, 11003 Cadiz, Spain
Interests: polyphosphate; PolyP; polymer; phosphate

Special Issue Information

Dear Colleagues,

Although the origin of inorganic polyphosphate (polyP) predates life, this linear polymer of phosphate groups is emerging as one of the most exciting biomolecules. The recent discoveries of implications of polyP in physiological processes such as bioenergetics, inflammation, neurodegeneration, and blood coagulation, among others, are being further explored nowadays, and the dissemination of this novel knowledge needs to be improved and accelerated. PolyP is ubiquitously present in any studied living organism, but different roles have been arising with their description in different organisms, tissues, and cell types. As innovative technologies to study polyP are being developed, there are a lot of expectations about the novel aspects yet to be revealed about this polymer. This Special Issue aims to communicate recent original research related to the different functions and characteristics of polyP and the new methodologies used for its study, as well as reviews that show the current state of understanding in these areas.

Dr. Félix A. Ruiz
Guest Editor

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Keywords

  • polyphosphate
  • PolyP
  • polymer
  • phosphate

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Published Papers (1 paper)

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Review

17 pages, 778 KiB  
Review
An Update on Polyphosphate In Vivo Activities
by Robert Schoeppe, Moritz Waldmann, Henning J. Jessen and Thomas Renné
Biomolecules 2024, 14(8), 937; https://doi.org/10.3390/biom14080937 - 2 Aug 2024
Cited by 3 | Viewed by 2277
Abstract
Polyphosphate (polyP) is an evolutionary ancient inorganic molecule widespread in biology, exerting a broad range of biological activities. The intracellular polymer serves as an energy storage pool and phosphate/calcium ion reservoir with implications for basal cellular functions. Metabolisms of the polymer are well [...] Read more.
Polyphosphate (polyP) is an evolutionary ancient inorganic molecule widespread in biology, exerting a broad range of biological activities. The intracellular polymer serves as an energy storage pool and phosphate/calcium ion reservoir with implications for basal cellular functions. Metabolisms of the polymer are well understood in procaryotes and unicellular eukaryotic cells. However, functions, regulation, and association with disease states of the polymer in higher eukaryotic species such as mammalians are just beginning to emerge. The review summarises our current understanding of polyP metabolism, the polymer’s functions, and methods for polyP analysis. In-depth knowledge of the pathways that control polyP turnover will open future perspectives for selective targeting of the polymer. Full article
(This article belongs to the Special Issue Inorganic Polyphosphate: A Multifaceted Biomolecule)
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