Biomolecules for Nuclear Imaging and Endoradiotherapy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 4017

Special Issue Editor


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Guest Editor
1. Departments of Clinical Neuroscience, Radiopharmacy and Oncology & Pathology, Karolinska Institute, 171 77 Stockholm, Sweden
2. MedTechLabs, Stockholm, Sweden
Interests: radiochemistry; molecular imaging; endoradiotherapy; theranostics; cell tracking

Special Issue Information

Dear Colleagues,

Biomolecules is presenting a Special Issue on the use of biomolecules in nuclear medicine! Therefore, we are inviting you to submit your exciting, state-of-the-art research involving antibodies, peptides or other biomolecules for nuclear imaging and therapy.

The field of nuclear medicine focuses on the imaging and treatment of diseases using biologically active compounds that are labelled with radioactive isotopes. More often than not, these compounds are derived from biogenic substances that are involved in the disease process. For example, the standard radiotracer for positron emission tomography (PET) imaging is a radiolabelled analogue of sugar, highly taken up by fast-growing tumours. Similarly, novel treatment strategies are based on (fragments of) antibodies and peptides, targeting specific pathological pathways and which are labelled with therapeutic isotopes to irradiate the unhealthy cells.

We are welcoming review papers, original research manuscripts and high-quality communications that explore the use of biomolecules for nuclear imaging and endoradiotherapy.

Dr. Jeroen A.C.M. Goos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molecular Imaging
  • Endoradiotherapy
  • Radiotracers
  • Radiopharmaceuticals
  • Positron Emission Tomography
  • Single-Photon Emission Computed Tomography
  • Cerenkov Imaging
  • Radioimmunotherapy
  • Peptide Receptor Radionuclide Therapy

Published Papers (1 paper)

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Research

12 pages, 1620 KiB  
Article
Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers
by Emma Jussing, Stefan Milton, Erik Samén, Mohammad Mahdi Moein, Lovisa Bylund, Rimma Axelsson, Jonathan Siikanen and Thuy A. Tran
Biomolecules 2021, 11(8), 1118; https://doi.org/10.3390/biom11081118 - 29 Jul 2021
Cited by 20 | Viewed by 3406
Abstract
By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different [...] Read more.
By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which negatively affects the radiolabeling yields. In this work, we significantly lowered the level of iron (Fe) impurities by adding ascorbate in the purification, and the resulting 68GaCl3could be utilized for high-yield radiolabeling of clinically relevant DOTA-based tracers. 68GaCl3 was cyclotron-produced and purified with ascorbate added in the wash solutions through the UTEVA resins. The 68Ga eluate was analyzed for radionuclidic purity (RNP) by gamma spectroscopy, metal content by ICP-MS, and by titrations with the chelators DOTA, NOTA, and HBED. The 68GaCl3eluate was utilized for GMP-radiolabeling of the DOTA-based tracers DOTATOC and FAPI-46 using an automated synthesis module. DOTA chelator titrations gave an apparent molar activity (AMA) of 491 ± 204 GBq/µmol. GMP-compliant syntheses yielded up to 7 GBq/batch [68Ga]Ga-DOTATOC and [68Ga]Ga-FAPI-46 (radiochemical yield, RCY ~ 60%, corresponding to ten times higher compared to generator-based productions). Full quality control (QC) of 68Ga-labelled tracers showed radiochemically pure and stable products at least four hours from end-of-synthesis. Full article
(This article belongs to the Special Issue Biomolecules for Nuclear Imaging and Endoradiotherapy)
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