CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 25
Special Issue Editors
Interests: CRISPR/Cas-directed gene eding; small molecules; HDR, NHEJ; regulation of genome editing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With the evolution of CRISPR-directed gene editing for the treatment of human diseases, the field of genetic medicine now holds more promise than ever. While most applications of gene editing tools for cancer have been indirect, such as the remodeling of T cells, direct in vivo strategies are beginning to emerge. In this Special Issue, we request contributions that center on using editors that orchestrate direct genetic changes within the tumor genome. We invite submissions exploring CRISPR gene editing from fundamental mechanism-of-action studies to translational applications in cancer therapy. Topics of interest include molecular insights of CRISPR/Cas systems in cancer-based models; novel approaches for altering the tumor microenvironment or disrupting oncogenic pathways; strategies for improving safety, efficiency, or precision of CRISPR/Cas systems for cancer therapy; and diagnostic applications of CRISPR technologies as tools for detection or molecular profiling. We accept submissions that describe novel delivery mechanisms that advance our knowledge of tissue or tumor-specific targeting, delivering the gene editing payload to the cell type where it can have the most positive impact.
Dr. Eric B. Kmiec
Dr. Kelly Banas
Guest Editors
Manuscript Submission Information
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Keywords
- CRISPR
- gene editing
- genome engineering
- cancer therapy
- solid tumors
- precision medicine
- translational research
- functional genomics
- tumor-specific targeting
- CRISPR diagnostics
- off-target effects
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