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Journals
Biomolecules
Special Issues
Cell Mechanics in Cell Biology and Biological Matter Physics
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Cell Mechanics in Cell Biology and Biological Matter Physics

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 1732

Special Issue Editor

Prof. Dr. Claudia Mierke

E-Mail Website
Guest Editor
Faculty of Physics and Earth Science, Department of Biological Physics Division (Cancer Research), Peter Debye Institute for Soft Matter Physics, University of Leipzig, Linnestrasse 5, 04103 Leipzig, Germany
Interests: focal adhesions; vinculin; Rac1; integrins; collagen; cell migration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a comprehensive overview of state-of-the-art cell mechanical research in physiological or pathological conditions, such as cancer or inflammation in cell biology and biological matter. We invite research papers that will consolidate our understanding in this area. The Special Issue will publish full research articles and reviews. Potential topics include, but are not limited to, the following research areas:

  • Effects of the microenvironment on cell mechanics;
  • The impact of specific molecules on cell mechanics;
  • How inflammatory processes alter the cell mechanics and their environments;
  • Cancer cell and cancer stem cell mechanics.

Prof. Dr. Claudia Mierke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

46 pages, 3197 KiB  
Review
Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis
by Claudia Tanja Mierke
Biomolecules 2024, 14(2), 184; https://doi.org/10.3390/biom14020184 - 03 Feb 2024
Viewed by 1532
Abstract
Tumor diseases become a huge problem when they embark on a path that advances to malignancy, such as the process of metastasis. Cancer metastasis has been thoroughly investigated from a biological perspective in the past, whereas it has still been less explored from [...] Read more.
Tumor diseases become a huge problem when they embark on a path that advances to malignancy, such as the process of metastasis. Cancer metastasis has been thoroughly investigated from a biological perspective in the past, whereas it has still been less explored from a physical perspective. Until now, the intraluminal pathway of cancer metastasis has received the most attention, while the interaction of cancer cells with macrophages has received little attention. Apart from the biochemical characteristics, tumor treatments also rely on the tumor microenvironment, which is recognized to be immunosuppressive and, as has recently been found, mechanically stimulates cancer cells and thus alters their functions. The review article highlights the interaction of cancer cells with other cells in the vascular metastatic route and discusses the impact of this intercellular interplay on the mechanical characteristics and subsequently on the functionality of cancer cells. For instance, macrophages can guide cancer cells on their intravascular route of cancer metastasis, whereby they can help to circumvent the adverse conditions within blood or lymphatic vessels. Macrophages induce microchannel tunneling that can possibly avoid mechanical forces during extra- and intravasation and reduce the forces within the vascular lumen due to vascular flow. The review article highlights the vascular route of cancer metastasis and discusses the key players in this traditional route. Moreover, the effects of flows during the process of metastasis are presented, and the effects of the microenvironment, such as mechanical influences, are characterized. Finally, the increased knowledge of cancer metastasis opens up new perspectives for cancer treatment. Full article
(This article belongs to the Special Issue Cell Mechanics in Cell Biology and Biological Matter Physics)
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