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Biomimetics
Special Issues
Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition
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Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetic Design, Constructions and Devices".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 6381

Special Issue Editor

Dr. Xiang Ge

E-Mail Website
Guest Editor
Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, School of Mechanical Engineering, Tianjin University, Tianjin 300354, China
Interests: biofabrication; biomaterials; antibacterial materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Special Issue collection of the journal Biomimetics, entitled “Functional Biomimetic Materials and Devices for Biomedical Applications”, for which we are collecting research articles, review articles, and short communications.

Recently, functional biomimetic materials and devices have attracted a lot of interest because they possess remarkable properties, such as a super-hydrophobic or super-hydrophilic ability, anti-fouling ability, anti-bacterial adhesion ability, bactericidal ability, and good cell affinity. Thus, researchers have started to explore the potential applications of these promising functional biomimetic materials and devices in biomedical fields, including orthopedics, dentistry, antibacterial biomaterials, anticancer biomaterials, and so on.

This Special Issue aims to showcase contributions from researchers and thinkers in all realms of functional biomimetic materials and devices and welcomes theoretical, experimental, and review contributions from biomimeticians, physicists, biologists, material scientists, mathematicians, doctors, and engineers alike who are engaged and interested in this fast-growing field. All papers will be published in an open-access format following a peer review.

Dr. Xiang Ge
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetic surface modification
  • dental and orthopedic implants
  • micro-/nano-structured surfaces
  • biofabrication
  • bio-manufacturing
  • biomedical
  • biomaterials
  • metals
  • ceramics
  • polymers
  • composites
  • hydrogels
  • antibacterial
  • anti-infection
  • anti-inflammation
  • anticancer
  • antitumor
  • biomineralization
  • additive manufacturing
  • 3D printing
  • biomimetic devices
  • wearable devices

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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13 pages, 67063 KB  
Article
Detergent-Based Decellularization Preserves Extracellular Matrix Ultrastructure in Ovine Soft Tissues
by Ibrahim E. Helal, Mahmoud F. Ahmed, Ahmed M. Abdellatif, Mohamed A. Hashem, Hatim A. Al-Abbadi and Elsayed Metwally
Biomimetics 2026, 11(5), 301; https://doi.org/10.3390/biomimetics11050301 - 26 Apr 2026
Viewed by 661
Abstract
Decellularized extracellular matrix (dECM) scaffolds derived from xenogeneic tissues represent promising biomaterials for tissue engineering. In this study, dECM scaffolds were developed and characterized from four ovine tissues—skin, tunica vaginalis, fascia lata, and pericardium—using a detergent-based decellularization protocol to evaluate decellularization efficiency and [...] Read more.
Decellularized extracellular matrix (dECM) scaffolds derived from xenogeneic tissues represent promising biomaterials for tissue engineering. In this study, dECM scaffolds were developed and characterized from four ovine tissues—skin, tunica vaginalis, fascia lata, and pericardium—using a detergent-based decellularization protocol to evaluate decellularization efficiency and extracellular matrix (ECM) preservation. Decellularization was performed using a sequential detergent-based protocol with sodium dodecyl sulfate and Triton X-100. Decellularization efficacy and matrix preservation were evaluated through gross examination, histological analysis, scanning electron microscopy (SEM), and residual DNA quantification. Gross inspection revealed increased translucency and reduced pigmentation in decellularized tissues compared with native counterparts, indicating effective cellular removal while maintaining overall tissue architecture. Histological assessment confirmed the complete absence of nuclear and cytoplasmic material, alongside preservation of collagen-rich extracellular matrix organization. SEM analysis demonstrated well-maintained ultrastructural features, including aligned collagen fibers and porous ECM architecture, with complete removal of epithelial and stromal cellular elements. Quantitative analysis revealed approximately 94% reduction in residual DNA content across all decellularized tissues compared with native controls. This study demonstrated that the employed detergent-based protocol reliably produces structurally preserved, acellular scaffolds from multiple ovine tissues. The resulting biomaterials exhibit structural characteristics that support their potential use in tissue engineering applications, pending further functional validation. Full article
(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition)
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17 pages, 2105 KB  
Article
Enhancing Polydimethylsiloxane with Silver Nanoparticles for Biomedical Coatings
by Axel Bachoux, Cédric Desroches, Laurence Bois, Catherine Journet, Aurore Berthier, Frédérique Bessueille-Barbier, Bérangère Toury and Nina Attik
Biomimetics 2025, 10(12), 846; https://doi.org/10.3390/biomimetics10120846 - 17 Dec 2025
Cited by 1 | Viewed by 842
Abstract
Silver nanoparticles (AgNPs) are widely used as antibacterial agents either as colloidal solutions or deposited on surfaces. However, the high concentration of AgNPs can lead to cytotoxicity, posing a hazard to healthy cells and tissues. Achieving a balance between antibacterial efficacy and cytocompatibility [...] Read more.
Silver nanoparticles (AgNPs) are widely used as antibacterial agents either as colloidal solutions or deposited on surfaces. However, the high concentration of AgNPs can lead to cytotoxicity, posing a hazard to healthy cells and tissues. Achieving a balance between antibacterial efficacy and cytocompatibility is crucial for biomedical applications. Polymeric coatings, especially those made from polydimethylsiloxane (PDMS) like Sylgard 184, are popular in biomedical applications due to their user-friendliness. We have developed a cost-effective method to reduce silver ions using the Si-H silane functions of PDMS in situ. Tetrahydrofuran (THF) acts as a solvent, inducing a swelling effect in PDMS, allowing silver ions from silver tetrafluoroborate (AgBF4) dissolved in THF to diffuse into the polymer and undergo reduction. This process results in PDMS functionalized with well-distributed 10 nm silver AgNPs. The resulting metal–polymer nanocomposites (MPNs) exhibit yellow shades and, based on qualitative Live/Dead staining observations, show no apparent cytotoxicity on human gingival fibroblasts. In addition, SEM analyses indicate a qualitative reduction in E. coli adhesion, suggesting an antibacterial anti-adhesive potential against this bacterial strain. Further studies should investigate the release profile of AgNPs in these composites, which could guide the development of new biocompatible coatings for phototherapy devices and enhance their long-term clinical performance. Full article
(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition)
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14 pages, 1815 KB  
Article
Bioactive Glass Modified by Sonochemistry Improves Peri-Implant Bone Repair in Ovariectomized Rats
by Marcelly Braga Gomes, Nathália Dantas Duarte, Gabriel Mulinari-Santos, Fábio Roberto de Souza Batista, Luy de Abreu Costa, Paulo Roberto Botacin, Paulo Noronha Lisboa-Filho and Roberta Okamoto
Biomimetics 2025, 10(12), 821; https://doi.org/10.3390/biomimetics10120821 - 8 Dec 2025
Viewed by 1964
Abstract
Estrogen deficiency is a primary cause of osteoporosis, compromising bone mineral density that may impair peri-implant healing. Given the compromised bone environment associated with estrogen deficiency, strategies such as particle reduction via sonochemistry are promising approaches to enhance regenerative outcomes. However, its effects [...] Read more.
Estrogen deficiency is a primary cause of osteoporosis, compromising bone mineral density that may impair peri-implant healing. Given the compromised bone environment associated with estrogen deficiency, strategies such as particle reduction via sonochemistry are promising approaches to enhance regenerative outcomes. However, its effects in promoting bone formation remain insufficiently explored. Therefore, this study evaluated the potential of two sonicated biomaterials to improve peri-implant repair in ovariectomized rats. Fifty female rats were allocated into five groups: blood clot (CLOT), Biogran® (BGN), sonicated Biogran® (BGS), Bio-Oss® (BON), and sonicated Bio-Oss® (BOS). Tibial peri-implant defects were created 30 days after ovariectomy and analyzed 28 days later by removal torque, microcomputed tomography, and confocal microscopy. BGS exhibited the highest removal torque (6.28 Ncm), followed by BON (5.37 Ncm), BOS (3.92 Ncm), BGN (3.15 Ncm), and CLOT (2.58 Ncm). Micro-CT revealed bone volume fraction (BV/TV) values of 8.07% (CLOT), 6.47% (BOS), 6.02% (BGS), 5.55% (BGN), and 2.84% (BON). For the trabecular number (Tb.N), BGS (1.11 mm−1) showed a significant increase compared with BGN (0.69 mm−1), p < 0.05. These findings show that sonochemically modified bioactive glass improves mechanical stability and trabecular microarchitecture under estrogen-deficient conditions. However, further studies are needed to standardize sonication parameters for different biomaterials and expand their translational applicability. Full article
(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition)
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Review

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34 pages, 3915 KB  
Review
Stimuli-Responsive Chitosan Hydrogels for Diabetic Wound Management: Comprehensive Review of Emerging Strategies
by Selvam Sathiyavimal, Ezhaveni Sathiyamoorthi, Devaraj Bharathi and Perumal Karthiga
Biomimetics 2025, 10(12), 807; https://doi.org/10.3390/biomimetics10120807 - 2 Dec 2025
Cited by 1 | Viewed by 2485
Abstract
Diabetic wounds remain a major clinical challenge due to impaired angiogenesis, chronic inflammation, oxidative stress, and persistent infection, all of which delay tissue repair. Conventional dressings provide only passive protection and fail to modulate the wound microenvironment effectively. Chitosan (CS) is a naturally [...] Read more.
Diabetic wounds remain a major clinical challenge due to impaired angiogenesis, chronic inflammation, oxidative stress, and persistent infection, all of which delay tissue repair. Conventional dressings provide only passive protection and fail to modulate the wound microenvironment effectively. Chitosan (CS) is a naturally derived polysaccharide inspired by biological structures in crustaceans and fungi. It has emerged as a multifunctional biomimetic polymer with excellent biocompatibility, antimicrobial activity, and hemostatic properties. Recent advances in biomimetic materials science have enabled the development of stimuli-responsive CS hydrogels. These systems can sense physiological cues such as pH, temperature, glucose level, light, and reactive oxygen species (ROS). These smart systems emulate natural wound healing mechanisms and adapt to environmental changes. They release bioactive agents on demand and promote tissue homeostasis through controlled angiogenesis and collagen remodeling. This review discusses the biomimetic design rationale, crosslinking mechanism, and emerging strategies underlying single and dual-responsive hydrogel systems. It further emphasizes how nature-inspired structural and functional designs accelerate diabetic wound repair and outlines the current challenges and future prospects for translating these bioinspired intelligent hydrogels into clinical wound care applications. Full article
(This article belongs to the Special Issue Functional Biomimetic Materials and Devices for Biomedical Applications: 5th Edition)
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