Immunonutrition: Biomedical Basis for Disease Management

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 6829

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Dear Colleagues,

Knowledge about the impact of immunonutritional agonists on citizens’ health can offer a way to reduce the risk of suffering chronic diseases and even offer a therapeutic potential on these. Innate and adaptive immune effectors operate sequentially and in distinct ways during normal development to prevent alterations in tissue metabolic homeostasis as well as to establish steady-state commensalism. Those are key to correct the distinctive stamp in alterations to the homeostasis of nutrients, leading to immunometabolic-based diseases with a strong impact on future morbidity rates and a reduction in the life expectancy of the population (i.e., non-alcoholic fatty liver disease, metabolic syndrome, cancer). There is evidence of the relevance of perinatal nutrition to developmental programming of innate immune effectors, worsening or improving their contribution to the risk of disease development. Viewed in the context of innate immune biology, immunonutrition as coadjutant strategy to pharmacological approaches can represent a path forward to help to selectively develop and maintain durable and long-lasting immune response(s). However, there remain key unanswered questions about immunonutritional factors that overall require a concerted effort to overcome the usually fragmented and compartmentalized approach to address their impact. Identification and development of immunonutritional agonists, as well as definition of their biomedical action based on life sciences, can greatly accelerate our progress toward precision medicine in health promotion.

Dr. Jose Laparra Llopis
Guest Editor

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Keywords

  • nutrients
  • innate and adaptive lymphocytes
  • myeloid cells
  • cancer
  • lipid homeostasis
  • microbiota

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Published Papers (1 paper)

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20 pages, 2579 KiB  
Review
NOD1-Targeted Immunonutrition Approaches: On the Way from Disease to Health
by Victoria Fernández-García, Silvia González-Ramos, Paloma Martín-Sanz, José M. Laparra and Lisardo Boscá
Biomedicines 2021, 9(5), 519; https://doi.org/10.3390/biomedicines9050519 - 6 May 2021
Cited by 8 | Viewed by 6157
Abstract
Immunonutrition appears as a field with great potential in modern medicine. Since the immune system can trigger serious pathophysiological disorders, it is essential to study and implement a type of nutrition aimed at improving immune system functioning and reinforcing it individually for each [...] Read more.
Immunonutrition appears as a field with great potential in modern medicine. Since the immune system can trigger serious pathophysiological disorders, it is essential to study and implement a type of nutrition aimed at improving immune system functioning and reinforcing it individually for each patient. In this sense, the nucleotide-binding oligomerization domain-1 (NOD1), one of the members of the pattern recognition receptors (PRRs) family of innate immunity, has been related to numerous pathologies, such as cancer, diabetes, or cardiovascular diseases. NOD1, which is activated by bacterial-derived peptidoglycans, is known to be present in immune cells and to contribute to inflammation and other important pathways, such as fibrosis, upon recognition of its ligands. Since immunonutrition is a significant developing research area with much to discover, we propose NOD1 as a possible target to consider in this field. It is relevant to understand the cellular and molecular mechanisms that modulate the immune system and involve the activation of NOD1 in the context of immunonutrition and associated pathological conditions. Surgical or pharmacological treatments could clearly benefit from the synergy with specific and personalized nutrition that even considers the health status of each subject. Full article
(This article belongs to the Special Issue Immunonutrition: Biomedical Basis for Disease Management)
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