MicroRNA and Its Role in Human Health
Deadline for manuscript submissions: 30 June 2024 | Viewed by 2278
MicroRNAs (miRs) are small, noncoding single-strand RNAs that impact human health. Emerging pieces of evidence indicate that miRs can be used as diagnostic or therapeutic agents, and in studying molecular mechanisms or novel signal pathways of the diseases. MiRs bind to the 3’-untranslated regions of the specific messenger RNAs that promote their degradation by perfect complementarity or translational repression by partial complementarity. Therefore, the target genes can be upregulated or downregulated according to the expression levels of the corresponding miRs in disease models. For these reasons, it will be intriguing to decipher the regulation or expression of novel miRs with the target genes. Regulation of miRs can be achieved by many techniques, including vector-based miR precursor or sponge, agomiR or antagomiR transfer, and knock-in or -out by CRISPR. High-throughput screening by miR array provides large-scale data mining to create disease associations. In this Special Issue, we aim to include a broad spectrum of disease models in which miRs and their target genes act as diagnostic, therapeutic, and pathogenic molecules. Original research articles and reviews are welcome. We look forward to receiving your contributions.
Dr. Shih-Yao Chen
Manuscript Submission Information
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- disease models
- disease associations
- molecular mechanism
- molecular diagnosis
- molecular therapy