Special Issue "Biofilms in Wounds: New Advances in Therapy and in Healing Management"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editors

Guest Editor
Dr. Célia F. Rodrigues Website E-Mail
LEPABE - Laboratory for Process Engineering Environment Biotechnology and Energy, Dep. Chemical Engineering, Faculty of Engineering -University of Porto, Portugal
Interests: biofilms; fungal and bacterial infections; resistance to antimicrobials; microfluidics; pathogens detection; alternative therapies; surface functionalization of biomaterials
Co-Guest Editor
Dr. Caitlin Light Website E-Mail
Binghamton University, Binghamton, NY, USA
Interests: biofilm development, biofilm dispersion, bacterial signaling, outer membrane vesicles, virulence and pathogenesis

Special Issue Information

Dear Colleagues,

Biofilm is the predominant mode of life for bacteria and yeasts and is presently implicated in numerous human diseases. In fact, the majority of non-healing wounds contain biofilms, contributing to the high global cost of chronic wounds. Non-healing wounds with biofilms have a low-grade and persistent inflammatory response, which leads to impaired epithelialization and granulation tissue formation, and reduced susceptibility to antimicrobial agents. Furthermore, a compromised host defense severely delays the healing of wounds in patients, contributing to infection.

Therefore, reducing the biofilm’s presence in wounds is, indeed, a critical element of effective wound care. Strategies to manage biofilm and encourage progression to wound healing are urgently needed.

We warmly welcome you to join us in this effort. Reviews or original research articles are most welcome. We look forward to receiving your contributions.

Dr. Célia Fortuna Rodrigues
Dr. Caitlin Light
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial therapy
  • phage therapy
  • anti-biofilm technologies
  • acute and chronic wound management
  • dressing technologies

Published Papers (2 papers)

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Review

Open AccessReview
Recent Advances in Non-Conventional Antimicrobial Approaches for Chronic Wound Biofilms: Have We Found the ‘Chink in the Armor’?
Biomedicines 2019, 7(2), 35; https://doi.org/10.3390/biomedicines7020035 - 30 Apr 2019
Cited by 1
Abstract
Chronic wounds are a major healthcare burden, with huge public health and economic impact. Microbial infections are the single most important cause of chronic, non-healing wounds. Chronic wound infections typically form biofilms, which are notoriously recalcitrant to conventional antibiotics. This prompts the need [...] Read more.
Chronic wounds are a major healthcare burden, with huge public health and economic impact. Microbial infections are the single most important cause of chronic, non-healing wounds. Chronic wound infections typically form biofilms, which are notoriously recalcitrant to conventional antibiotics. This prompts the need for alternative or adjunct ‘anti-biofilm’ approaches, notably those that account for the unique chronic wound biofilm microenvironment. In this review, we discuss the recent advances in non-conventional antimicrobial approaches for chronic wound biofilms, looking beyond standard antibiotic therapies. These non-conventional strategies are discussed under three groups. The first group focuses on treatment approaches that directly kill or inhibit microbes in chronic wound biofilms, using mechanisms or delivery strategies distinct from antibiotics. The second group discusses antimicrobial approaches that modify the biological, chemical or biophysical parameters in the chronic wound microenvironment, which in turn enables the disruption and removal of biofilms. Finally, therapeutic approaches that affect both, biofilm bacteria and microenvironment factors, are discussed. Understanding the advantages and limitations of these recent approaches, their stage of development and role in biofilm management, could lead to new treatment paradigms for chronic wound infections. Towards this end, we discuss the possibility that non-conventional antimicrobial therapeutics and targets could expose the ‘chink in the armor’ of chronic wound biofilms, thereby providing much-needed alternative or adjunct strategies for wound infection management. Full article
(This article belongs to the Special Issue Biofilms in Wounds: New Advances in Therapy and in Healing Management)
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Open AccessReview
Current Status of In Vitro Models and Assays for Susceptibility Testing for Wound Biofilm Infections
Biomedicines 2019, 7(2), 34; https://doi.org/10.3390/biomedicines7020034 - 30 Apr 2019
Abstract
Biofilm infections have gained recognition as an important therapeutic challenge in the last several decades due to their relationship with the chronicity of infectious diseases. Studies of novel therapeutic treatments targeting infections require the development and use of models to mimic the formation [...] Read more.
Biofilm infections have gained recognition as an important therapeutic challenge in the last several decades due to their relationship with the chronicity of infectious diseases. Studies of novel therapeutic treatments targeting infections require the development and use of models to mimic the formation and characteristics of biofilms within host tissues. Due to the diversity of reported in vitro models and lack of consensus, this review aims to provide a summary of in vitro models currently used in research. In particular, we review the various reported in vitro models of Pseudomonas aeruginosa biofilms due to its high clinical impact in chronic wounds and in other chronic infections. We assess advances in in vitro models that incorporate relevant multispecies biofilms found in infected wounds, such as P. aeruginosa with Staphylococcus aureus, and additional elements such as mammalian cells, simulating fluids, and tissue explants in an attempt to better represent the physiological conditions found at an infection site. It is hoped this review will aid researchers in the field to make appropriate choices in their proposed studies with regards to in vitro models and methods. Full article
(This article belongs to the Special Issue Biofilms in Wounds: New Advances in Therapy and in Healing Management)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Review
Title: Antimicrobial Peptides against Bacterial Biofilms: Advantages and Limits
Authors: Giovanna  Batoni, etc.
Biomedicines, EISSN 2227-9059, Published by MDPI AG
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