Special Issue "Acute Myeloid Leukemia and Autophagy"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: 14 May 2021.

Special Issue Editors

Dr. Magali Humbert
E-Mail Website
Guest Editor
Institute of Pathology University of Bern, Bern 3008, Switzerland
Interests: autophagy; chaperone-mediated autophagy; acute myeloid leukemias; breast cancer; retinoids; differentiation therapy; transcription factors
Dr. Paula Ludovico
E-Mail Website
Guest Editor
Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal
Interests: acute myeloid leukemia; metabolism; aging; autophagy/mitophagy; cell death programs

Special Issue Information

Dear Colleagues,

Acute myeloid leukemia (AML) is a blood cancer characterized by a block in differentiation of leukemia blast that has acquired aberrant self-renewal potential. With an estimated 5-year overall survival of less than 30%, AML is one of the deadliest cancers. Within the past few years, advanced molecular technology has allowed for a better understanding of AML biology and pathogenesis. Unfortunately, treatment strategies have not significantly changed since 1970, and therapy failure and relapses remain high. The molecular landscape of AML affects key hematopoietic signaling pathways such as apoptosis, proliferation, and differentiation. Therefore, a better understanding of AML biology and pathology will lead to investigating new therapy strategies combining targeted agents with standard chemotherapeutic agents.

Several reports have demonstrated that AML cells have deregulated autophagy. Because of the heterogeneity of the disease, the role of autophagy as a tumor suppressor or promotor in AML is still under debate. 

For this Special Issue of Biology, we invite authors to submit original research papers and reviews that cover mechanisms or potential therapy strategies in AML involving autophagy pathways. We look forward to reading your contributions.

Dr. Paula Ludovico
Dr. Magali Humbert
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • acute myeloid leukemia
  • autophagy
  • lysosomes
  • blood
  • leukemia stem cell
  • therapy resistance
  • differentiation
  • hematopoiesis

Published Papers

This special issue is now open for submission.
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