Biological Mechanisms of Photoprotection and Innovative Strategies for UV Protection

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1155

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Sciences, State University of Maringa, Maringá 87020-900, Brazil
Interests: biological activity; mechanisms of drug action; cosmetics; applied microbiology; biologically active natural products; photochemoprotection; cutaneous biometrics

Special Issue Information

Dear Colleagues,

The skin is constantly exposed to solar radiation, and its continued exposure causes it to undergo biochemical processes, including oxidative stress, which can lead to inflammation, apoptosis and even DNA damage. It is, therefore, extremely important to search for new compounds and strategies that reverse cellular damage and protect the skin against UV radiation.

Hence, we are pleased to invite you to publish in this Special Issue: Biological Mechanisms of Photoprotection and Innovative Strategies for UV Protection, which addresses the natural mechanisms by which the skin reverses damage caused by ultraviolet (UV) radiation and explores advanced strategies to improve this protection. The development of sunscreens and cosmetics that mimic the skin's natural protective mechanisms, as well as improve this effect, is currently becoming a target of research. This issue encompasses topics such as endogenous and exogenous antioxidants, oxidative stress, cellular mechanisms of photoprotection, in vitro and in vivo photochemoprotection, photobiology, the action of sunscreens and multifunctional formulations on the skin, and skin biometrics.

We look forward to receiving your contributions.

Prof. Dr. Celso Vataru Nakamura
Guest Editor

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Keywords

  • antioxidants
  • oxidative stress
  • photoprotection
  • UV radiation
  • photobiology
  • skin damage
  • skin biometrics
  • sunscreens

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Published Papers (1 paper)

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Research

15 pages, 2681 KiB  
Article
A Triple-Precursor Blend as a Topical Solution to Protect the Skin Against Environmental Damage
by Ping Gao, Xue Xiao, Zhuang Zhou, Hong Zhang, Raghupathi Subramanian, Anuchai Sinsawat and Xuelan Gu
Biology 2025, 14(3), 266; https://doi.org/10.3390/biology14030266 - 5 Mar 2025
Viewed by 882
Abstract
The epidermis acts as the body’s primary defense, relying on components like lipids, HA and GSH for skin barrier function, hydration and resistance to oxidative stress. However, limitations in the topical application of these biomolecules call for novel approaches. This study investigates the [...] Read more.
The epidermis acts as the body’s primary defense, relying on components like lipids, HA and GSH for skin barrier function, hydration and resistance to oxidative stress. However, limitations in the topical application of these biomolecules call for novel approaches. This study investigates the efficacy of Pro-GHL, a blend of free fatty acids, acetylglucosamine and GSH amino acid precursors (GAPs), designed to replenish skin lipids, HA and GSH through de novo biosynthesis. Using primary human keratinocytes, Pro-GHL demonstrated superior antioxidant and anti-inflammatory capacities compared to each individual component under the challenge of UVB or blue light. In 3D skin equivalent models (EpiKutis®), Pro-GHL enhanced skin barrier function. In addition, Pro-GHL prevented the development of pigmentation in pigmented 3D skin equivalent models (MelaKutis®) subjected to UVB irradiation or Benzo[a]pyrene exposure. Together, these results highlight Pro-GHL’s potential as a novel, effective and comprehensive skincare approach to fortify the skin’s defense system from within and prevent the accumulation of tissue damage in response to extrinsic stressors. Full article
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