Dear Colleagues,

The concomitant incidence of immunodeficiency and autoimmunity in early-onset patients may represent a paradox, yet it has been documented in an expanding number of conditions. The use of unbiased molecular studies to identify novel forms of inborn errors of immunity, along with in-depth functional studies of biological samples from affected cases, continues to clarify the novel pathogenesis underlying immune dysregulation and autoinflammation in patients with an altered central or peripheral tolerance, and contributes to fighting pathogens. The genetic etiology of autoimmune disease has the power to dramatically transform patient treatment, shifting clinical care from non-specific therapies to targeted therapies. The late onset of autoimmune disease in adult cases suggests that multiple genetic and non-genetic factors, including epigenetic alterations, contribute to disease pathogenesis. In this Special Issue, we welcome the submission of original research and review articles related to this topic.

Dr. Hassan Abolhassani
Dr. Gholamreza Azizi
Guest Editors

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• autoimmunity
• autoinflammation
• immune dysregulation
• inborn errors of immunity
• primary immunodeficiency