Advances in Thrombosis and Vascular Biology
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 677
Special Issue Editor
Interests: blood and vascular biology; thrombosis; hemostasis; vascular injury
Special Issue Information
Dear Colleagues,
Hemostasis plays an extremely important role in preventing life-threatening blood loss in response to the disruption of the integrity of blood vessels. After vascular damage, thrombus formation is rapidly initiated to seal the injury. Platelets circulating in the blood are immediately recruited to the site of vascular injury and adhere to the exposed sub-endothelium collagen via the collagen receptor on the platelet surface. The interaction between collagen and its receptor initiates platelet signal transduction and leads to platelet activation and aggregation via the interaction of platelet integrin aIIbb3 and its ligands fibrinogen and von Willebrand factor. Concomitantly, tissue factor activates blood coagulation, which ultimately leads to the generation of thrombin and fibrin. The interaction between fibrin and platelet integrin aIIbb3 induces the process called clot retraction and the formation of stable thrombi. Although hemostasis is a pivotal physiological response and thrombus formation failure results in severe hemorrhagic disorders, excessive or pathological thrombus formation can lead to severe thrombotic diseases, such as myocardial infraction and stroke, which is a major cause of morbidity and mortality worldwide. Thus, thrombus formation must be tightly regulated. With the advancement of new technology and the development of a new thrombosis model, we present recent advances in thrombosis and hemostasis in this Special Issue.
Dr. Lu Wang
Guest Editor
Manuscript Submission Information
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Keywords
- blood and vascular biology
- thrombosis
- hemostasis
- vascular injury
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