Special Issue "New Horizons in Immune Tolerance"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 1373

Special Issue Editor

Dr. Tiago Granja
E-Mail Website
Guest Editor
CBIOS – Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal
Interests: inflammation; innate immunity; chemotatic cues; microvasculature

Special Issue Information

Dear Colleagues and Fellow Researchers,

I would like to invite you to submit some of your outstanding work to this MDPI Special Edition on Immune Tolerance. The constant necessity of recognition of self-antigens and pathogens has a deep impact in our society. Tolerance is fundamental to immunity due to the continuous selection of higher antigen specificity. Lymphocyte education is critical to healthy humoral immunity, and a fail in self-tolerance is the hallmark for the development of auto-immunity. In addition to the well-studied impact of genetics, the pressure of surroundings presents unprecedented challenges to bench and clinical research in the field. Tolerance mechanisms have been widely described from animal models and genomic and proteomic studies. However, the impact of inflammation, infection, and cancer in breaking immune tolerance during defense, surveillance, and homeostasis remains unclear.

It is therefore relevant to discuss beyond antigen affinity and lymphocyte selection. Plasticity can be affected by immunopotentiators and suppressants, sugar metabolism can be correlated with bacterial symbiosis, and membrane neuro-immune molecules can fail to discriminate between senescence and on-going infection. Alternatively, on-going inflammation can yield long-distance cues inducing macrophage differentiation, affect controlled cell death, and control lipid signaling during resolution.

This Special Issue aims to encourage the submission of original research and review manuscripts focused in experimental and clinical work in the field of immune tolerance. Aiming to widen the horizon of the field, this title will approach classic and modern methodologies and focus on the roles of cellular communication and molecular regulation as a bridge between clinical manifestation and the development of auto-immunity.

Dr. Tiago Granja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • tolerance
  • immunity
  • plasticity
  • inflammation
  • resolution
  • differentiation
  • symbiosis
  • antigen affinity
  • autoimmunity

Published Papers (1 paper)

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IL-10 Producing Regulatory B Cells Mediated Protection against Murine Malaria Pathogenesis
Biology 2022, 11(5), 669; https://doi.org/10.3390/biology11050669 - 27 Apr 2022
Cited by 2 | Viewed by 997
Various immune cells are known to participate in combating infection. Regulatory B cells represent a subset of B cells that take part in immunomodulation and control inflammation. The immunoregulatory function of regulatory B cells has been shown in various murine models of several [...] Read more.
Various immune cells are known to participate in combating infection. Regulatory B cells represent a subset of B cells that take part in immunomodulation and control inflammation. The immunoregulatory function of regulatory B cells has been shown in various murine models of several disorders. In this study, a comparable IL-10 competent B-10 cell subset (regulatory B cells) was characterized during lethal and non-lethal infection with malaria parasites using the mouse model. We observed that infection of Balb/c mice with P. yoelii I 7XL was lethal, and a rapid increase in dynamics of IL-10 producing B220+CD5+CD1d+ regulatory B cells over the course of infection was observed. However, animals infected with a less virulent strain of the parasite P. yoelii I7XNL attained complete resistance. It was observed that there is an increase in the population of regulatory B cells with an increase of parasitemia; however, a sudden drop in the frequency of these cells was observed with parasite clearance. Adoptive transfer of regulatory B cells to naïve mice followed by infection results in slow parasite growth and enhancement of survival in P. yoelii 17XL (lethal) infected animals. Adoptively transferred regulatory B cells also resulted in decreased production of pro-inflammatory cytokine (IFN-γ) and enhanced production of anti-inflammatory cytokine (IL-10). It infers that these regulatory B cells may contribute in immune protection by preventing the inflammation associated with disease and inhibiting the parasite growth. Full article
(This article belongs to the Special Issue New Horizons in Immune Tolerance)
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