Genome Plasticity in Disease, Evolution and Adaptation
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2594
Special Issue Editors
Interests: structural variations; evolutionary genetics; cytogenomics; cytogenetics; centromeres
Interests: genomics; plant genetics; molecular breeding; gene expression; sequencing; bioinformatics
Interests: bioinformatics; molecular biology; genome variation; cancer genetics
Special Issue Information
Dear Colleagues,
Some regions of eukaryotic genomes are characterized by an outstanding plasticity. This has been demonstrated in animal as well as in plant genomes. Genomic plasticity can be due either to an inherent feature, as observed for centromeric regions, or to the presence of “triggering” elements, such as regions enriched in segmental duplications or transposable elements.
Plastic genomic regions are more prone to genomic rearrangements, allowing for structural variants or neocentromere seeding. Besides having negative consequences, as shown in human genomic disorders, these regions confer to genomes the ability to evolve with high dynamicity, adapt to environmental changes also in order to respond to stress, and contribute to speciation.
Nowadays, there is much interest in studying these regions not only to increase our knowledge of genomes structure and evolution, but also to understand their functional effect on inter-individual phenotypic differences and the mechanisms involved in the genesis of genomic plasticity.
This Special Issue welcomes the submission of research articles and reviews on genome plasticity and genomic variability. More in detail, submissions should be focused on the effects of these two mechanisms on the evolution of genomes and the adaptation of organisms, including the plasticity of the transcriptome and regulatory elements.
Dr. Claudia R. Catacchio
Dr. Maria Francesca Cardone
Dr. Alberto L’Abbate
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genome plasticity;
- centromeres;
- structural variation;
- genomic rearrangements;
- evolution;
- plant adaptation;
- chromothripsis.
