Boron Neutron Capture Therapy: Biological Principles and Clinical Applications
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 408
Special Issue Editors
Interests: particle therapy; proton; carbon-ion therapy; boron neutron capture therapy; BNCT; heavy-ion therapy; radiotherapy; radiation oncology
Special Issues, Collections and Topics in MDPI journals
Interests: particle therapy; heavy-ion radiotherapy; carbon-ion radiotherapy; boron neutron capture therapy; artificial intelligence; machine learning; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There has been a strong renewed interest in boron neutron capture therapy (BNCT) over the past several decades to improve the therapeutic ratio of radiotherapy in often treatment-resistant cancers. Recent clinical research has shown the promise of BNCT in traditionally radioresistant tumors, although there remains a paucity of both pre-clinical and clinical data. Although BNCT has been used in various forms for decades, recent advances in the biological agents and technology of neutron generation have led to a resurgence of interest.
The aim of our Special Issue is to provide a forum for discussion on the recent advances in BNCT, with a specific focus on the radiobiological and biological advances underlying the renewed interest in BNCT as well as how these advances translate into improved clinical outcomes. Topics of interest for our Special Issue include, but are not limited to: developments in novel boron agents, the targeting of specific cellular targets with boron, the cellular/molecular response to treatment BNCT, the use of non-boronated compounds in a neutron capture reaction (such as gadolinium), radiobiological modeling, and clinical outcomes. Additional topics will be considered at the discretion of the Guest Editors.
Our Special Issue welcomes the submission of original research, review articles, meta-analyses, protocols, and any other relevant articles focusing on the topic of BNCT. Basic biology, physics, and clinical research manuscripts are welcome and encouraged, as BNCT remains an international and multidisciplinary technology.
Dr. Timothy D. Malouff
Dr. Daniel K. Ebner
Guest Editors
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Keywords
- boron neutron capture therapy
- BNCT
- particle therapy
- neutron therapy
- radiotherapy
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