Cellular Senescence in Development, Regeneration, Aging, and Cancer
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 31 December 2026 | Viewed by 111
Special Issue Editor
Interests: cellular senescence; aging; cancer; obesity; metabolism; geroscience; age-related diseases; inflammaging; senolytics
Special Issue Information
Dear Colleagues,
Cellular senescence is a phenomenon characterized by the cessation of cell division; it is a complex cell fate with significant implications for both cancer and aging. Cellular senescence serves as a critical tumor-suppressive mechanism by halting the proliferation of damaged cells but can also promote tumor progression and therapy resistance by creating a pro-tumorigenic microenvironment. Additionally, the accumulation of senescent cells during aging contributes to chronic diseases, as their pro-inflammatory secretome drives chronic inflammation, tissue dysfunction, and metabolic dysregulation, exacerbating age-related pathologies. Furthermore, recent studies have uncovered functional roles for senescence in embryonic development and regeneration.
In this Special Issue, original research articles and reviews are welcome to address the latest advances in understanding cellular senescence at the intersection of cancer and aging, as well as its roles in development and regeneration. Research areas may include (but are not limited to) the following: molecular mechanisms or markers of cellular senescence, the role of the immune system in senescent cell clearance and interaction, novel therapeutic strategies targeting senescence (senolytics and senomorphics), implications of cellular senescence in cancer and aging-related diseases, and roles of cell senescence in regeneration, development, and longevity across species.
By integrating insights from geroscience, cancer biology, regenerative medicine, developmental biology, and immunology, this Special Issue aims to highlight fundamental research and emerging translational strategies to target cellular senescence for extending healthspan and enhancing anti-cancer therapies and improve our understanding of the regenerative and developmental processes influenced by cellular senescence.
I look forward to receiving your contributions.
Dr. Selim Chaib
Guest Editor
Manuscript Submission Information
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Keywords
- cellular senescence
- aging
- cancer
- obesity
- metabolism
- geroscience
- age-related diseases
- SASP
- senolytics
- biomarkers
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