ABCG1 and HDL in Health and Disease
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 2 July 2025 | Viewed by 972
Special Issue Editors
Interests: ABCA1; ABCG1; atherosclerosis; cholesterol efflux; miR-33; reverse cholesterol transport
Special Issue Information
Dear Colleagues,
Intracellular cholesterol content is crucial to influencing several conditions and disease states, as altering intracellular cholesterol levels impacts membrane fluidity, lipid raft formation/disruption, and signaling pathways. Cellular cholesterol metabolism is regulated by numerous factors and the removal of cellular cholesterol is considered to be primarily controlled by cholesterol efflux. Two major proteins which regulate cholesterol efflux are the transporter ABCG1 and the lipoprotein HDL. However, both of these proteins appear to modulate other biological effects besides the removal of cholesterol. For instance, ABCG1 expression has been shown to be anti-inflammatory, and HDL is considered to have both antioxidant and anti-inflammatory properties. Interestingly, while HDL is largely thought to be atheroprotective, some data suggest certain HDL particles may be harmful to health. Moreover, it is not entirely elucidated whether the biological effects that ABCG1 and HDL exhibit rely entirely on ABCG1/HDL-mediated cholesterol efflux. It is also poorly understood whether ABCG1 expression in certain cells and tissues may either promote health or be a factor in the development of certain diseases.
This Special Issue of Biology welcomes any novel and innovative research articles as well as comprehensive reviews which focus on the impact of ABCG1 and/or HDL in the context of health and disease.
Dr. Alexis Stamatikos
Dr. Terri F. Bruce
Guest Editors
Manuscript Submission Information
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Keywords
- atherosclerosis
- cancer
- cardiovascular disease
- cholesterol efflux
- diet-related disease
- inflammation
- lipid raft
- reverse cholesterol transport
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