Dysregulated Enzyme Expression and Function in Cancer and Human Disease
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 186
Special Issue Editors
Interests: enzymology; protein isolation and purification; cellular biochemistry; oxidative stress; cancer biochemistry; mechanisms of drug resistance
Special Issues, Collections and Topics in MDPI journals
Interests: antioxidants; antiproliferative natural products; cellular biochemistry, angiogenesis; stem cells; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is open to contributions that explore the role of enzymes in pathological settings, going beyond their traditional use as biological markers to consider them as active drivers of human disease. Enzymes can influence multiple cellular pathways and are uniquely positioned to integrate metabolic, redox, inflammatory, and epigenetic signals. For this reason, they often play a decisive role in shaping cellular plasticity and in determining how cells respond to oxidative stress or pharmacological treatments. Enzyme deregulation rarely occurs at a single level. It can involve changes in catalytic activity or protein expression, but also post-translational modifications, altered subcellular localization, or interactions with specific protein targets. Together, these mechanisms allow enzymes to be considered as regulators of cellular processes such as oxidative stress, chronic inflammation, and metabolic reprogramming, all of which strongly influence disease development and progression. We therefore welcome studies that address enzyme function and regulation using both established and emerging experimental approaches. In addition to conventional methodologies, contributions based on omics technologies—such as proteomics or lipidomics—as well as 3D culture systems and co-culture models from molecular and pharmacological targeting of enzymes are particularly encouraged.
Dr. Roberta Moschini
Dr. Francesca Felice
Guest Editors
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Keywords
- enzyme dysregulation
- enzymatic activity
- metabolic reprogramming
- oxidative stress
- cellular plasticity
- cancer biology
- drug resistance
- enzyme-targeted therapies
- cancer angiogenesis
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