Advances in Diagnosis and Treatment of Prostate Cancer

Dear Colleagues,

Prostate cancer is the second most diagnosed cancer and the fifth leading cause of cancer death among men worldwide, with an estimated 1,414,000 new cancer cases and 375,304 deaths in 2020. Although it often has an indolent course, prostate cancer remains the leading cause of cancer death in men. Although tissue biopsy remains the standard of care for diagnosis, the identification and characterization of the disease have become increasingly personalized through advances in functional and molecular imaging modalities (e.g., MRI, PET, SPECT), as well as from the emergence of biomarkers. In particular, prostate-specific membrane antigen (PSMA), in general, is overexpressed in prostate cancers in proportion to aggressiveness, and as tracers of PET, SPECT has been shown to be superior to a number of other tracers in identifying the local and metastatic sites of disease. Targeting PSMA is also proving efficacious in treatment when anti-PSMA ligands are conjugated to radiolabeled elements such as lutetium-177, yttrium-90, iridium-192, gold-198, ytterbium-169, etc. Recent advances in the synthesis of nanomaterials with diagnostic and therapeutic capabilities have been rapidly reshaping the landscape of precision medicine specific to prostate cancer. Active targeting nanocarriers are versatile platforms which synergistically integrate diagnosis and multiple therapy strategies, including chemotherapy, radiotherapy, immunotherapy, photodynamic therapy, etc. This Special Issue of Bioengineering aims to provide multiple perspectives on the advances in diagnosis and treatment of prostate cancer by bringing together worldwide contributions on the clinical and pre-clinical studies of targeted imaging and therapy for prostate cancer.

Dr. Junwei Shi
Dr. Wensi Tao
Dr. Eriko Katsuta
Prof. Dr. Yu-Chang Tyan
Guest Editors

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