Advances in Enabling Technologies for Bone Tissue Engineering

Dear Colleagues,

The field of tissue engineering focuses on a combination of scaffolds, cells, and bioactive factors to initiate repair, replacement, or regeneration of damaged or diseased tissue. Since its definition in the early 1990s, the field has expanded greatly, with research focused on every tissue in the body. Despite this rapid growth in many different tissue types, bone remains one of the leading topics of study with scaffold design spanning an extensive list of fabrication methods. Scaffolds have been formed using 3D printing, hydrogels, electrospinning, and many other techniques to capture the necessary porosity, mechanical properties, and biocompatibility to induce bone regeneration. Further, the materials used in these fabrication methods have been adapted from simple polymers to combined constructs with gradient properties to directly tailor the direction and rate of formation. These complex structures range from natural to synthetic polymers, as well as metals and ceramics to recapitulate the mineralized matrix. Further, external additives have been incorporated to improve bioactivity and healing potential, especially in environments prone to infection or weakened strength.

This special issue of Bioengineering on “Advances in Enabling Technologies for Bone Tissue Engineering” will focus on innovative techniques for inducing bone formation ranging, for example, from material combinations to the fabrication of a bone framework to electrical stimulation to signaling for inducing new tissue. This Special Issue will focus on all new and exciting technology for studying and inducing bone formation in diseased and damaged tissue, where all relevant research areas are welcome.

Dr. Katherine R. Hixon
Dr. Shang Song
Guest Editors

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