Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.3
3.8
Journals
Bioengineering
Special Issues
Surgical Wound Infections and Management
share announcement

Surgical Wound Infections and Management

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1955

Special Issue Editors

Prof. Dr. Sharon Henry

E-Mail Website
Guest Editor
Division of Trauma and Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, USA
Interests: soft tissue infections
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marcelo A. F. Ribeiro Jr.

E-Mail Website
Guest Editor
Division of Trauma and Critical Care, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, USA
Interests: trauma; acute care surgery; wounds; open abdomen
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Surgical wound infections represent a significant challenge in postoperative care, contributing to extended hospital stays, increased medical costs, and heightened patient morbidity and mortality. We will provide a review of the state of our current knowledge of this problem. This Special Issue will explore the multifaceted aspects of these infections, providing a comprehensive resource for medical professionals.

Epidemiology and Incidence:

This section will cover the global and regional prevalence of surgical wound infections, highlighting trends and incidences. Understanding the epidemiology is crucial for developing targeted prevention strategies.

Groups Affected:

Focus will be given to vulnerable populations, including the elderly, immunocompromised patients, and those with comorbidities such as diabetes. This will shed light on risk factors and the need for tailored preventive measures. Burn wound infections are a particularly vexing problem. Approaches to the diagnosis and management of this difficulty problem will also be explored.

Medical and Surgical Treatments:

We will delve into the latest advancements in medical and surgical treatments, including prophylactic antibiotics, antiseptic techniques, guidelines, protocols, and innovative surgical approaches. Articles will explore evidence-based practices and emerging therapies aimed at reducing infection rates.

Outcomes and Complications:

We will examine the short- and long-term outcomes of surgical wound infections, addressing potential complications such as sepsis, delayed wound healing, and chronic pain. Understanding these outcomes is essential for improving patient care and recovery processes.

You may choose our Joint Special Issue in Journal of Clinical Medicine.

Prof. Dr. Sharon Henry
Prof. Dr. Marcelo A. F. Ribeiro Jr.
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical wound infections
  • epidemiology
  • incidence
  • risk factors
  • prophylactic antibiotics
  • antiseptic techniques
  • patient outcomes
  • complications
  • postoperative care
  • vulnerable populations
  • burn wound infection
  • antimicrobials
  • bioengineered materials for wounds and infections

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 322 KiB  
Article
Limited Diagnostic Value of Blood Cultures in Patients with Soft Tissue Infections Transferred to a Quaternary Care Center
by Mira H. Ghneim, Gregory M. Schrank, William Teeter, Brooke Andersen, Anna Brown and Quincy K. Tran
Bioengineering 2025, 12(6), 609; https://doi.org/10.3390/bioengineering12060609 - 3 Jun 2025
Viewed by 337
Abstract
Introduction: Patients with soft tissue infection are often encountered in clinical practice. The mainstay of treatment typically includes antimicrobial therapy, followed by surgical debridement when indicated. Blood cultures are often performed prior to starting the first dose of antibiotics. However, when patients require [...] Read more.
Introduction: Patients with soft tissue infection are often encountered in clinical practice. The mainstay of treatment typically includes antimicrobial therapy, followed by surgical debridement when indicated. Blood cultures are often performed prior to starting the first dose of antibiotics. However, when patients require transfer to tertiary/quaternary-level care for more advanced surgical interventions, blood cultures are often repeated despite patients being on broad-spectrum antibiotics. Our study aims to investigate the utility of blood cultures following transfer to a higher level of care. Methods: This is a retrospective study involving adult patients (≥18 years of age) who were transferred to a quaternary academic center with soft tissue infections between 15 June 2018 and 15 February 2022. Patients with incomplete medical records and/or without blood culture data after arrival were excluded. The primary outcome was the rate of positive blood cultures post-transfer. Descriptive analyses were performed, and comparisons between groups were expressed as absolute differences and 95% CI. Results: We analyzed 303 patients with a mean (+/−SD) age of 54 (14) years, and 199 (66%) were male. Necrotizing soft tissue infections (NSTIs) predominated, 198 patients (65%), with a majority of the NSTIs involving the perineum (112, 37%). The prevalence of positive blood cultures was 20 (7%) for pre-transfer and 14 (5%) for post-transfer. Among post-transfer positive blood cultures, 3 (21%) were coagulase-negative Staphylococcus aureus, with 2 (14%) cases each for the blood culture categories of polymicrobial, methicillin-sensitive Staphylococcus aureus, and Enterococcus faecalis, and 2 (14%) with Candida species. Among 112 patients with NSTIs of the perineum, 2 (14%) patients had positive blood cultures post-transfer, compared with 110 (38%) patients with negative blood cultures (difference 24%, 95% CI −0.40, −0.12, p < 0.001). Conclusions: For patients with soft tissue infection, the prevalence of positive blood culture after arrival at our quaternary care center was low at 5%. Pathogenic cases of positive blood cultures after transfer were polymicrobial, methicillin-sensitive Staphylococcus aureus and Candida species. However, the low number of post-transfer positive blood cultures limits the strength of the inference and should be interpreted cautiously. Further studies are necessary to confirm our observation. Clinicians at tertiary/quaternary care centers should consider the utility of obtaining blood cultures from patients with soft tissue infections transferred from other facilities. Full article
(This article belongs to the Special Issue Surgical Wound Infections and Management)
►▼ Show Figures

Figure 1

Review

Jump to: Research

13 pages, 410 KiB  
Review
Steal Syndrome in Free Flap Microvascular Reconstruction of the Lower Extremity: Systematic Review of Incidence, Risk Factors, and Surgical Management
by Georgios Karamitros, Ilias Iliadis, Raymond A. Pensy and Gregory A. Lamaris
Bioengineering 2025, 12(6), 647; https://doi.org/10.3390/bioengineering12060647 - 12 Jun 2025
Abstract
Background: Steal syndrome in the setting of microvascular reconstruction refers to a phenomenon whereby blood flow is diverted from the native tissue to the free flap, leading to ischemia and potential limb loss. In the present study, we aim to comprehensively evaluate [...] Read more.
Background: Steal syndrome in the setting of microvascular reconstruction refers to a phenomenon whereby blood flow is diverted from the native tissue to the free flap, leading to ischemia and potential limb loss. In the present study, we aim to comprehensively evaluate the occurrence and management of steal syndrome in free flap reconstruction of the lower extremities. Methods: A thorough literature search was conducted across the MEDLINE, Embase, Cochrane Library, and Scopus databases up to 29 January 2025. Studies were selected based on predefined inclusion criteria focusing on free flap microvascular reconstruction in the lower extremities with a focus on steal syndrome. Two independent reviewers assessed and extracted data. Results: Three studies were included, involving seven patients, with a mean age of 65.66 ± 5.89 years, who developed steal syndrome following free flap microvascular reconstruction. The most common revision involved below-the-knee amputation (BKA) due to ischemic complications. Comorbidities such as peripheral vascular disease (PVD), diabetes, and hypertension were present in all cases. The majority of anastomoses (85.7%) were end-to-side (ETS), with only one case utilizing a flow-through configuration. The majority of cases (n = 5, 71.4%) were reconstructed using latissimus dorsi (LD) flaps, with the remaining two cases using rectus abdominis (n = 1) and gracilis (n = 1) flaps. The recipient vessel was the anterior tibial artery in two patients (28.6%), the dorsalis pedis artery in two patients (28.6%), and the popliteal artery in three patients (42.9%). The most common salvage procedure was below-the-knee amputation (BKA), performed in four patients (57.1%). One patient required revision of the venous anastomosis and flap debridement, followed by a Chopart amputation (n = 1, 14.3%). Conclusions: The occurrence of steal syndrome in free flap microvascular reconstruction of the lower extremities is rare but can lead to significant complications, including amputation. The findings indicate that steal syndrome is more likely in patients with pre-existing vascular conditions such as PVD and diabetes. While surgical technique and flap type may influence its development, further studies are needed to identify specific anatomical and clinical predictors. The absence of a unified treatment guideline underscores the need for further investigation into effective management strategies to prevent amputation and optimize patient outcomes. Full article
(This article belongs to the Special Issue Surgical Wound Infections and Management)
►▼ Show Figures

Figure 1

12 pages, 238 KiB  
Review
Nanomedicine and Its Role in Surgical Wound Infections: A Practical Approach
by Malak Bentaleb, Mohammed Abdulrahman and Marcelo A. F. Ribeiro Jr
Bioengineering 2025, 12(2), 137; https://doi.org/10.3390/bioengineering12020137 - 31 Jan 2025
Cited by 2 | Viewed by 1153
Abstract
Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise of antibiotic-resistant pathogens, it is crucial to develop new innovative wound materials to manage surgical wound infections using methods that facilitate drug delivery agents [...] Read more.
Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise of antibiotic-resistant pathogens, it is crucial to develop new innovative wound materials to manage surgical wound infections using methods that facilitate drug delivery agents and rely on materials other than antimicrobials. Nanoparticles, in particular, have captured researchers’ interest in recent years due to their effectiveness in wound care. They can be classified into three main types: inorganic nanoparticles, lipid-based nanoparticles, and polymeric nanoparticles. Several studies have demonstrated the effectiveness of these new technologies in enhancing wound-healing times and reducing bacterial burden. However, further research is essential to thoroughly evaluate the safety and toxicity of these materials before they can be integrated into routine surgical practice. Full article
(This article belongs to the Special Issue Surgical Wound Infections and Management)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop