Special Issue "Nanomaterials in Medical Engineering"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 10 December 2021.

Special Issue Editor

Dr. Morgan Hamon
E-Mail Website
Guest Editor
School of Medicine, University of California, Los Angeles, LA 90007, USA
Interests: biomedical engineering; tissue engineering; regenerative medicine; biomaterials; developmental engineering; microfluidics

Special Issue Information

Dear Colleagues,

The “Nanomaterials in Medical Engineering” section of Applied Sciences covers an important domain of research and development. As the field of biomedical engineering advances, the demand for highly functionalized biomaterials increases. In recent years, nanomaterials have become increasingly useful in biomedicine, with noteworthy applications in various domains, including diagnosis, drug delivery systems, prostheses, and implants.

This Special Issue intends to gather original scientific peer-reviewed articles and review articles featuring important and recent developments or achievements in nanomaterial research, with an emphasis on medical applications and potential applications. Authors who are well-known experts in their domain are invited to submit their contribution at any time until the end of June 2021. Papers can cover either the experimental or theoretical aspect, or both aspects, of nanomaterials (organic, inorganic, or hybrid) in medical applications, including diagnosis, drug delivery, tissue engineering, regenerative medicine, prostheses, and implants.

Dr. Morgan Hamon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

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Article
Enhancement of Antimicrobial Activity of Alginate Films with a Low Amount of Carbon Nanofibers (0.1% w/w)
Appl. Sci. 2021, 11(5), 2311; https://doi.org/10.3390/app11052311 - 05 Mar 2021
Cited by 5 | Viewed by 603
Abstract
The World Health Organization has called for new effective and affordable alternative antimicrobial materials for the prevention and treatment of microbial infections. In this regard, calcium alginate has previously been shown to possess antiviral activity against the enveloped double-stranded DNA herpes simplex virus [...] Read more.
The World Health Organization has called for new effective and affordable alternative antimicrobial materials for the prevention and treatment of microbial infections. In this regard, calcium alginate has previously been shown to possess antiviral activity against the enveloped double-stranded DNA herpes simplex virus type 1. However, non-enveloped viruses are more resistant to inactivation than enveloped ones. Thus, the viral inhibition capacity of calcium alginate and the effect of adding a low amount of carbon nanofibers (0.1% w/w) were explored here against a non-enveloped double-stranded DNA virus model for the first time. The results of this study showed that neat calcium alginate films partly inactivated this type of non-enveloped virus and that including that extremely low percentage of carbon nanofibers (CNFs) significantly enhanced its antiviral activity. These calcium alginate/CNFs composite materials also showed antibacterial properties against the Gram-positive Staphylococcus aureus bacterial model and no cytotoxic effects in human keratinocyte HaCaT cells. Since alginate-based materials have also shown antiviral activity against four types of enveloped positive-sense single-stranded RNA viruses similar to SARS-CoV-2 in previous studies, these novel calcium alginate/carbon nanofibers composites are promising as broad-spectrum antimicrobial biomaterials for the current COVID-19 pandemic. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Engineering)
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Review

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Review
Nanotechnology, Nanomedicine, and the Kidney
Appl. Sci. 2021, 11(16), 7187; https://doi.org/10.3390/app11167187 - 04 Aug 2021
Cited by 1 | Viewed by 461
Abstract
The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this [...] Read more.
The kidneys are vital organs performing several essential functions. Their primary function is the filtration of blood and the removal of metabolic waste products as well as fluid homeostasis. Renal filtration is the main pathway for drug removal, highlighting the importance of this organ to the growing field of nanomedicine. The kidneys (i) have a key role in the transport and clearance of nanoparticles (NPs), (ii) are exposed to potential NPs’ toxicity, and (iii) are the targets of diseases that nanomedicine can study, detect, and treat. In this review, we aim to summarize the latest research on kidney-nanoparticle interaction. We first give a brief overview of the kidney’s anatomy and renal filtration, describe how nanoparticle characteristics influence their renal clearance, and the approaches taken to image and treat the kidney, including drug delivery and tissue engineering. Finally, we discuss the future and some of the challenges faced by nanomedicine. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Engineering)
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Review
Nanoarchitectures in Management of Fungal Diseases: An Overview
Appl. Sci. 2021, 11(15), 7119; https://doi.org/10.3390/app11157119 - 31 Jul 2021
Viewed by 518
Abstract
Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of [...] Read more.
Fungal infections, from mild itching to fatal infections, lead to chronic diseases and death. Antifungal agents have incorporated chemical compounds and natural products/phytoconstituents in the management of fungal diseases. In contrast to antibacterial research, novel antifungal drugs have progressed more swiftly because of their mild existence and negligible resistance of infections to antifungal bioactivities. Nanotechnology-based carriers have gained much attention due to their magnificent abilities. Nanoarchitectures have served as excellent carriers/drug delivery systems (DDS) for delivering antifungal drugs with improved antifungal activities, bioavailability, targeted action, and reduced cytotoxicity. This review outlines the different fungal diseases and their treatment strategies involving various nanocarrier-based techniques such as liposomes, transfersomes, ethosomes, transethosomes, niosomes, spanlastics, dendrimers, polymeric nanoparticles, polymer nanocomposites, metallic nanoparticles, carbon nanomaterials, and nanoemulsions, among other nanotechnological approaches. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Engineering)
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Review
Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth
Appl. Sci. 2021, 11(15), 6929; https://doi.org/10.3390/app11156929 - 28 Jul 2021
Cited by 3 | Viewed by 475
Abstract
In biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibrous mats, [...] Read more.
In biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibrous mats, however, have been reported to promote cell growth, adhesion, and proliferation. Here, we give an overview of the different attempts at cultivating mammalian cells on electrospun nanofiber mats for biotechnological and biomedical purposes. Starting with a brief overview of the different electrospinning methods, resulting in random or defined fiber orientations in the nanofiber mats, we describe the typical materials used in cell growth applications in biotechnology and tissue engineering. The influence of using different surface morphologies and polymers or polymer blends on the possible application of such nanofiber mats for tissue engineering and other biotechnological applications is discussed. Polymer blends, in particular, can often be used to reach the required combination of mechanical and biological properties, making such nanofiber mats highly suitable for tissue engineering and other biotechnological or biomedical cell growth applications. Full article
(This article belongs to the Special Issue Nanomaterials in Medical Engineering)
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