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Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth

Faculty of Engineering and Mathematics, Bielefeld University of Applied Sciences, Interaktion 1, 33619 Bielefeld, Germany
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Author to whom correspondence should be addressed.
Academic Editor: Morgan Hamon
Appl. Sci. 2021, 11(15), 6929; https://doi.org/10.3390/app11156929
Received: 30 June 2021 / Revised: 26 July 2021 / Accepted: 27 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Nanomaterials in Medical Engineering)
In biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibrous mats, however, have been reported to promote cell growth, adhesion, and proliferation. Here, we give an overview of the different attempts at cultivating mammalian cells on electrospun nanofiber mats for biotechnological and biomedical purposes. Starting with a brief overview of the different electrospinning methods, resulting in random or defined fiber orientations in the nanofiber mats, we describe the typical materials used in cell growth applications in biotechnology and tissue engineering. The influence of using different surface morphologies and polymers or polymer blends on the possible application of such nanofiber mats for tissue engineering and other biotechnological applications is discussed. Polymer blends, in particular, can often be used to reach the required combination of mechanical and biological properties, making such nanofiber mats highly suitable for tissue engineering and other biotechnological or biomedical cell growth applications. View Full-Text
Keywords: cell growth; electrospinning; nanofibrous membrane; adherent cells; biomedicine cell growth; electrospinning; nanofibrous membrane; adherent cells; biomedicine
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MDPI and ACS Style

Tanzli, E.; Ehrmann, A. Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth. Appl. Sci. 2021, 11, 6929. https://doi.org/10.3390/app11156929

AMA Style

Tanzli E, Ehrmann A. Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth. Applied Sciences. 2021; 11(15):6929. https://doi.org/10.3390/app11156929

Chicago/Turabian Style

Tanzli, Ewin, and Andrea Ehrmann. 2021. "Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth" Applied Sciences 11, no. 15: 6929. https://doi.org/10.3390/app11156929

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