Bone Histogenesis and Regeneration

Dear Colleagues,

The sophisticated processes leading to bone histogenesis (during skeletal organogenesis and bone turnover) and bone regeneration (after injuries or bone diseases) are currently not fully elucidated. It is not only bone cells that are involved in bone formation but also other tissues/organs (skeletal muscles, adipose tissue, etc.), acting in endocrine/paracrine-like manners via crosstalk between various actors belonging to different systems. Morphological changes as well as signaling pathways occurring during bone formation are to be deepened in a translational perspective. Collecting data from different fields (morphofunctional investigations, biomolecular analysis, clinical experimentations) is crucial to obtain interdisciplinary approaches with the final goal to improve tissue engineering strategies, in particular aimed at bone regeneration. This is particularly pivotal in a society with prolonged life expectancy, having the consequence to observe various pathologies, increasingly affecting the aging subjects. Focusing on the skeletal system, not only does bone fragility induce more susceptibility to fractures (often not accompanied by a good self-repairing ability), but metabolic imbalances also often induce failed bone regeneration. We hope that researchers with different expertises will consider contributing to this Special Issue, as it is only by sharing knowledge that we can hope to solve the problem of bone regeneration in critical conditions.

Prof. Carla Palumbo
Dr. Alberto Smargiassi
Guest Editors

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