Special Issue "Advances of Biomedical Optics—The 15th International Conference on Laser Applications in Life Sciences (LALS 2018)"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (28 February 2019).

Special Issue Editors

Prof. Zeev Zalevsky
E-Mail Website
Guest Editor
Faculty of Engineering, Bar-Ilan University, Ramat-Gan, 52900, Israel
Interests: Electro optics
Special Issues and Collections in MDPI journals
Prof. Dror Fixler
E-Mail Website
Guest Editor
Faculty of Engineering; Head of the Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 5290002, Israel
Interests: fluorescence lifetime and anisotropy decay; fluorescence lifetime imaging; biological imaging based on fluorescence parameters; light–tissue interaction; nanophotonics
Special Issues and Collections in MDPI journals
Prof. Dr. Kirill Larin
E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA
Interests: optical coherence tomography; microscopy; biomechanics; developmental biology

Special Issue Information

Dear Colleagues,

Lasers play a major role in life science research, as well as in various industrial applications and devices. Following the International Conference on Laser Applications in Life Sciences (LALS) 2018 (https://orelcrfi.wixsite.com/laser), which will be held during November 18–20, in Bar Ilan University, Ramat Gan, Israel, we will organize a Special Issue, soliciting submission of papers dealing with the applicability and the integration of lasers in biomedical optics and imaging, spectroscopy, therapy and bio-photonic sensing and, more specifically, in the topic specified below:

  1. Fundamentals, hybridization and future approaches:
  • Laser tissue interaction
  • Emerging technologies and applications
  • Optical Coherence Tomography
  • Photo-acoustics
  1. Sensing:
  • Biomedical imaging and sensors
  • Laser spectroscopy, microscopy and nanoscopy
  • Nonlinear Imaging and Multiphoton Microscopy
  • Cytometry and High Content Screening
  1. Treatment:
  • Laser therapy and devices for: Photo-thermal, Photodynamic and Low laser level therapy
  • Laser acoustics remote treatment and visualization
  • Opto- and thermo-genetics: Controlling the brain with light
  • Towards nanomedical treatment: usage of nanoparticles, nanoplasmonics and teranostics

Prof. Dr. Zeev Zalevsky
Prof. Dr. Dror Fixler
Prof. Dr. Kirill Larin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Laser tissue interaction
  • Emerging technologies and applications
  • Photo-acoustics
  • Optical Coherence Tomography
  • Biomedical imaging and sensors
  • Laser spectroscopy, microscopy and nanoscopy
  • Nonlinear Imaging and Multiphoton Microscopy
  • Cytometry and High Content Screening
  • Laser therapy and devices
  • Photo-thermal, Photodynamic and Low laser level therapy
  • Laser acoustics remote treatment and visualization
  • Opto- and thermo-genetics
  • Nanoparticles in nanomedicine
  • Nanoplasmonics in nanomedicine
  • Teranostics

Published Papers (4 papers)

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Research

Open AccessArticle
Towards Bimodal Optical Monitoring of Photodynamic Therapy with Targeted Nanoconstructs: A Phantom Study
Appl. Sci. 2019, 9(9), 1918; https://doi.org/10.3390/app9091918 - 10 May 2019
Abstract
Increase of the efficiency of photodynamic therapy (PDT) requires the development of advanced protocols employing both novel photosensitizer (PS) carriers and aids for online monitoring. Nanoconstructs may be comprised of a photosensitizer, chemotherapy drugs, or inhibitors of molecular pathways that support cancer growth. [...] Read more.
Increase of the efficiency of photodynamic therapy (PDT) requires the development of advanced protocols employing both novel photosensitizer (PS) carriers and aids for online monitoring. Nanoconstructs may be comprised of a photosensitizer, chemotherapy drugs, or inhibitors of molecular pathways that support cancer growth. In this paper, we analyze the efficiency of a bimodal approach involving fluorescence and optoacoustic imaging in monitoring drug distribution and photobleaching. The study evaluates typical sensitivities of these techniques to the presence of the two key moieties of a nanoconstruct: benzoporphyrin derivatives (BPD) serving as a PS, and IRDye800 acting as a contrast agent. Both imaging modalities employ dual-wavelength probing at the wavelengths corresponding to absorption peaks of BPD and IRDye800, which enables their separate detection. In an experiment on a tissue-mimicking phantom with inclusions containing separate BPD and IRDye800 solutions, fluorescence imaging demonstrated higher contrast as compared to optoacoustic imaging for both components, though strong light scattering in the surrounding media restricted accurate localization of the markers. It was also sensitive to photobleaching, which is a measure of PDT efficiency. Optoacoustic imaging demonstrated sufficient sensitivity to both components, though less than that of fluorescence imaging, however, it enabled depth-resolved detection of an absorber and estimation of its relative content. Employment of the bimodal approach in monitoring of PS photobleaching adds to its potential in intraprocedural PDT monitoring. Full article
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Open AccessArticle
A Measurement System for Quasi-Spectral Determination of Absorption and Scattering Parameters of Veterinary Tissue Phantoms
Appl. Sci. 2019, 9(8), 1632; https://doi.org/10.3390/app9081632 - 19 Apr 2019
Abstract
This paper describes the construction of a system for the quasi-spectral determination of absorption and scattering parameters of animal tissue phantoms. Several tissue phantoms, including one reference and two modified for examination, were prepared from polydimethylsiloxane (PDMS). The phantoms were measured using a [...] Read more.
This paper describes the construction of a system for the quasi-spectral determination of absorption and scattering parameters of animal tissue phantoms. Several tissue phantoms, including one reference and two modified for examination, were prepared from polydimethylsiloxane (PDMS). The phantoms were measured using a system based on an integrating sphere and the light sources of wavelengths commonly used for the treatment of various diseases in veterinary medicine, including 635 nm (red), 532 nm (green) and 447 nm (blue). The obtained results are consistent with data provided in reference sources and can also be approximated for the entire spectral range of visible radiation (380–780 nm). The developed system is suitable for further measurements of phantoms, which can be adapted to imitate different tissues. Full article
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Open AccessArticle
Increasing Resolution in Live Cell Microscopy by Structured Illumination (SIM)
Appl. Sci. 2019, 9(6), 1188; https://doi.org/10.3390/app9061188 - 20 Mar 2019
Abstract
In the context of various approaches to super-resolution microscopy, structured illumination microscopy (SIM) offers several advantages: it needs rather low light doses (with a low risk of phototoxicity or photobleaching), is comparably fast and flexible concerning the use of microscopes, objective lenses and [...] Read more.
In the context of various approaches to super-resolution microscopy, structured illumination microscopy (SIM) offers several advantages: it needs rather low light doses (with a low risk of phototoxicity or photobleaching), is comparably fast and flexible concerning the use of microscopes, objective lenses and cameras, and has potential for 3D imaging. This paper describes an experimental setup for SIM with first diffraction orders of a spectral light modulator (SLM) creating an interference pattern in two dimensions. We kept this system rather compact with a comparably large illuminated object field, validated it with nano-beads and applied it further to living cells for imaging the cytoskeleton, mitochondria or cell nuclei with a resolution slightly above 100 nm. Its advantages, challenges and limitations—concerning cameras, acquisition time, depth of imaging, light exposure, and combining it with further super-resolving methods—are discussed. Full article
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Open AccessArticle
Fiber-Optic System for Intraoperative Study of Abdominal Organs during Minimally Invasive Surgical Interventions
Appl. Sci. 2019, 9(2), 217; https://doi.org/10.3390/app9020217 - 09 Jan 2019
Cited by 2
Abstract
The paper presents the results of experimental measurements of endogenous fluorescence and blood perfusion in patients with pathology of the organs of hepatopancreatoduodenal area in vivo. A custom setup combining channels for fluorescence spectroscopy (excitation wavelengths of 365 nm and 450 nm) and [...] Read more.
The paper presents the results of experimental measurements of endogenous fluorescence and blood perfusion in patients with pathology of the organs of hepatopancreatoduodenal area in vivo. A custom setup combining channels for fluorescence spectroscopy (excitation wavelengths of 365 nm and 450 nm) and laser Doppler flowmetry (1064 nm) with fibre optical probe for nondestructive laparoscopic measurements has been developed and applied during minimally invasive operation procedure. Preliminary measurements with two aforementioned channels have been performed at specified excitation wavelengths. The possibility of obtaining fluorescence spectra and laser Doppler flowmetry signals in vivo during minimally invasive interventions was shown. Obtained data show perspectives of further research on technical and methodological development of optical diagnostic methods for minimally invasive surgery. The obtained results can be used to provide a deeper understanding of pathological processes influence on optical properties of abdominal organs tissues, which will ultimately help surgeons to determine the state of vitality in tissues and mucous membranes directly during the process of surgical intervention. Full article
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