Bacteriophages in Therapy and Biosensor Devices

Dear Colleagues,

The search for more specific, robust and novel recognition probes is one of the major problems of innovative biosensor and therapy devices. In these applications, the bio-probes represent a new frontier to obtaining a specific and high affinity system to detect the analyte. Recent studies have employed bacteriophages (or simple phage) as a valid alternative to standard bio-probes. In this prospective, wild-type and engineered phage have been used with success as new recognition probes on the sensor substrates and/or in phage therapy to overcome the constant increase in microbial resistance to antibiotics. Moreover, phage derivatives, such as phage receptor-binding proteins (RBPs) and, most lately, phage-display peptides (PDPs), have been applied in the development of simple and economic systems that are able to detect several abiotic components, such as biotic target in diagnostic assay and in innovative targeting therapeutic devices.

The aim of this Special Issue is to provide an overview of the last generation of phage-based proof of concept, point of care and complete devices applied in the diagnostic and therapy field.

As Guest Editors of this Special Issue, we invite you to submit research articles, review articles, and short communications related to Bacteriophages in Therapy and Biosensor Devices.

Dr. Domenico Franco
Dr. Laura Maria De Plano
Prof. Dr. Salvatore P.P. Guglielmino
Guest Editors

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