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Advances in Natural Antimicrobial Compounds: Discovery, Synthesis, Characterization, and Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 85

Special Issue Editors


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Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Interests: antibacterial activity; microbiology; infectious disease; epidemiology; public health; antimicrobials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial resistance is gaining more attention as one of the greatest threats to the prevention and treatment of an increasing number of infections. Thus, there is a pressing need for the continuous supply of novel antibiotics to combat such diseases. At present, the high occurrence of resistance to all major classes of known antibiotics represents a new challenge, and new classes of antibacterial compounds are urgently required to respond to this unmet clinical need. Natural resources such as microorganisms, plants, and animals are used to extract novel compounds, of which microbes are a major source of new antimicrobial agents.

This Special Issue aims to explore natural antimicrobial compounds, emphasizing their synthesis, characterization, and diverse applications in clinical and environmental contexts within the framework of the One Health approach.

Dr. Carla Sabia
Dr. Ramona Iseppi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • bacteriocins
  • antibacterial compounds
  • antibiofilm activity
  • antibiotic resistance

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Published Papers (1 paper)

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Review

14 pages, 547 KiB  
Review
Antibiofilm Potential of Natural Essential Oils
by Renata Nurzyńska-Wierdak
Appl. Sci. 2025, 15(11), 5847; https://doi.org/10.3390/app15115847 - 22 May 2025
Abstract
Commonly available essential oils (EOs) are pure aromatic substances derived from natural plant sources (fresh or dried raw materials), with broad biological activity, including antimicrobial activity. The activity of EOs is of great interest due to the serious problem of diseases caused by [...] Read more.
Commonly available essential oils (EOs) are pure aromatic substances derived from natural plant sources (fresh or dried raw materials), with broad biological activity, including antimicrobial activity. The activity of EOs is of great interest due to the serious problem of diseases caused by microorganisms. Pathogenic microorganisms (PAMs) show increased resistance to physical and chemical factors due to their association with a form of specific biological membrane called biofilm (BF), which is resistant to extreme conditions and significantly hinders effective therapy. The decreasing effectiveness of antibiotics, combined with the increasing resistance of microorganisms, has prompted the search for alternative antimicrobial (AM) therapies. EOs and some of their components are currently considered as potential agents useful in the prevention, treatment, and control of infections transmitted by microbial BF. In combination with antibiotics, EOs can prevent the transfer of resistance to AM agents due to the synergistic antibiofilm (ABF) effect. BF inhibition by EO is not based on killing bacterial cells but on the inhibition of the quorum sensing (QS) pathway. EOs also affect growth regulation, nutritional balance, and energy conversion in bacteria. It can be assumed that this group of substances will be of significant importance in the treatment of infectious diseases in the near future. This article reviews the results of the latest research on essential oils and their main components as potential factors limiting/inhibiting the development of PAMs. Full article
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