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Trends and Perspectives in Bacterial Biofilms

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 486

Special Issue Editors


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Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Interests: microbiology; multidrug resistance; essential oils; bacterial biofilm; bacteriocin and probiotics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Interests: antibacterial activity; microbiology; infectious disease; epidemiology; public health; antimicrobials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bacterial biofilms are complex aggregates of single or multiple bacterial species residing in an exopolysaccharide matrix that adhere to biotic or abiotic surfaces.

Adherent cells are well known for their resistance to various antimicrobial agents and environmental stresses.

Therefore, biofilms pose significant challenges when pathogenic bacteria or fungi adhere to medical devices and wounds, causing chronic infections that are difficult and sometimes impossible to treat.

Bacterial biofilms pose a significant hazard not only in the medical field but also in other fields such as food safety and water quality.

For this reason, improvements in microbiological control are needed to facilitate the use of novel, rapid, and easy-to-use methods to detect and eradicate microbial biofilms.

This Special Issue welcomes original research and reviews that address, but are not limited to, biofilm formation and strategies to control and eradicate microbial biofilms.

Dr. Ramona Iseppi
Dr. Patrizia Messi
Dr. Carla Sabia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • dry biofilm
  • pathogens
  • microbial communities
  • eradication
  • prevention
  • new methods

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Published Papers (1 paper)

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Research

16 pages, 5181 KiB  
Article
Bioactive Glass Preloaded with Antibiotics for Delivery of Long-Term Localized Drug Release Exhibiting Inherent Antimicrobial Activity
by Dana Almasri and Yaser Dahman
Appl. Sci. 2025, 15(10), 5363; https://doi.org/10.3390/app15105363 - 11 May 2025
Viewed by 281
Abstract
Bacterial infections caused by biofilms are often difficult to treat due to the resistant nature of the latter, which require high concentrations of antibiotics to be applied for prolonged periods to achieve complete eradication. This study aimed to design a new drug delivery [...] Read more.
Bacterial infections caused by biofilms are often difficult to treat due to the resistant nature of the latter, which require high concentrations of antibiotics to be applied for prolonged periods to achieve complete eradication. This study aimed to design a new drug delivery system for long-term drug release for the treatment of bacterial infections. Specifically, bioactive glass preloaded with vancomycin (BG-V) and synthesized without any thermal treatment was designed to load higher percentages of the drug and release it slowly over time. In this study, BG-V was-synthesized using a solution containing vancomycin, with glass being formed around it by adding metal precursors to this solution. The BG-V was then left to dry at room temperature to form a white powder with vancomycin trapped in the structure. The successful synthesis of BG-V was confirmed by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning emission microscopy, and nitrogen adsorption–desorption analysis. The results showed that BG-V was successfully developed using FTIR, showing vancomycin within the BG-V structure. After the drug release, BG-V showed great bioactivity, as indicated by the XRD and bacterial studies. The result shows that drug release is controlled by a combination of diffusion through the matrix and the gradual erosion of the delivery system. Full article
(This article belongs to the Special Issue Trends and Perspectives in Bacterial Biofilms)
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